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NONMEM经验:美西律和利多卡因治疗患者血清浓度数据分析

Experience with NONMEM: analysis of serum concentration data in patients treated with mexiletine and lidocaine.

作者信息

Vozeh S, Wenk M, Follath F

出版信息

Drug Metab Rev. 1984;15(1-2):305-15. doi: 10.3109/03602538409015068.

DOI:10.3109/03602538409015068
PMID:6547664
Abstract

The generality and flexibility of the computer package NONMEM also confront the user with the difficult task of choosing the model which best describes the data at hand. With two practical examples we show how one may proceed in building the population model for serum concentration measurements. Features of NONMEM are presented which help the user to make the choice among different models.

摘要

计算机程序包NONMEM的通用性和灵活性也让用户面临一项艰巨任务,即选择最能描述手头数据的模型。通过两个实际例子,我们展示了如何构建用于血清浓度测量的群体模型。还介绍了NONMEM的一些特性,这些特性有助于用户在不同模型之间做出选择。

相似文献

1
Experience with NONMEM: analysis of serum concentration data in patients treated with mexiletine and lidocaine.NONMEM经验:美西律和利多卡因治疗患者血清浓度数据分析
Drug Metab Rev. 1984;15(1-2):305-15. doi: 10.3109/03602538409015068.
2
Experience with NONMEM: analysis of routine phenytoin clinical pharmacokinetic data.NONMEM的应用经验:苯妥英钠常规临床药代动力学数据分析
Drug Metab Rev. 1984;15(1-2):293-303. doi: 10.3109/03602538409015067.
3
[Comparative study of the anti-arrhythmic activity of mexiletine and lidocaine in ventricular hyperkinetic arrhythmias].美西律与利多卡因对室性心动过速抗心律失常活性的比较研究
G Ital Cardiol. 1981;11(4):468-76.
4
Electrophysiological properties of mexiletine assessed with respect to plasma concentrations.美西律的电生理特性与血浆浓度的相关性评估。
Eur J Cardiol. 1980 Feb;11(2):115-21.
5
[Mexiletine in the treatment of lidocaine-resistant ventricular tachycardia. Preliminary results].[美西律治疗利多卡因耐药性室性心动过速。初步结果]
G Ital Cardiol. 1982;12(6):457-9.
6
Simple gas-liquid chromatographic method for the measurement of mexiletine and lignocaine in blood-plasma or serum.
J Chromatogr. 1979 Feb 1;169:295-301. doi: 10.1016/0021-9673(75)85053-9.
7
Possible mechanism for pharmacokinetic interaction between lidocaine and mexiletine.利多卡因与美西律之间药代动力学相互作用的可能机制。
Clin Pharmacol Ther. 2002 May;71(5):389-97. doi: 10.1067/mcp.2002.124077.
8
Tocainide and mexiletine. Orally effective lidocaine analogues.妥卡尼和美西律。口服有效的利多卡因类似物。
Arch Intern Med. 1985 Mar;145(3):417-8.
9
Liquid chromatographic determination of mexiletine and tocainide in human plasma with fluorescence detection after reaction with a modified o-phthalaldehyde reagent.用改良邻苯二甲醛试剂反应后荧光检测法对人血浆中美西律和妥卡尼进行液相色谱测定。
J Chromatogr. 1985 Nov 8;344:221-30. doi: 10.1016/s0378-4347(00)82022-8.
10
Comparative haemodynamic effects of lidocaine, mexiletine, and disopyramide.
J Cardiovasc Pharmacol. 1984 May-Jun;6(3):483-90.

引用本文的文献

1
Population Pharmacokinetics of Intravenous Lidocaine in Adults: A Systematic Review.成人静脉利多卡因的群体药代动力学:系统评价。
Clin Pharmacokinet. 2024 May;63(5):623-643. doi: 10.1007/s40262-024-01373-4. Epub 2024 May 4.
2
Interaction between structural, statistical, and covariate models in population pharmacokinetic analysis.群体药代动力学分析中结构模型、统计模型和协变量模型之间的相互作用。
J Pharmacokinet Biopharm. 1994 Apr;22(2):165-77. doi: 10.1007/BF02353542.
3
Rapid prediction of individual dosage requirements for lignocaine.
Clin Pharmacokinet. 1984 Jul-Aug;9(4):354-63. doi: 10.2165/00003088-198409040-00005.
4
Performance of Bayesian feedback to forecast lidocaine serum concentration: evaluation of the prediction error and the prediction interval.贝叶斯反馈预测利多卡因血清浓度的性能:预测误差和预测区间的评估。
J Pharmacokinet Biopharm. 1985 Apr;13(2):203-12. doi: 10.1007/BF01059399.
5
Population pharmacokinetics. Theory and clinical application.群体药代动力学。理论与临床应用。
Clin Pharmacokinet. 1986 Sep-Oct;11(5):387-401. doi: 10.2165/00003088-198611050-00004.
6
Population pharmacokinetics of phenytoin in Singapore Chinese.
Eur J Clin Pharmacol. 1990;39(2):177-81. doi: 10.1007/BF00280055.
7
Clinical pharmacokinetics 1990.临床药代动力学,1990年
Clin Pharmacokinet. 1990 Jan;18(1):1-19. doi: 10.2165/00003088-199018010-00001.
8
An evaluation of point and interval estimates in population pharmacokinetics using NONMEM analysis.使用NONMEM分析法对群体药代动力学中的点估计和区间估计进行评估。
J Pharmacokinet Biopharm. 1991 Feb;19(1):87-112. doi: 10.1007/BF01062194.
9
Bayesian parameter estimation and population pharmacokinetics.
Clin Pharmacokinet. 1992 Jun;22(6):447-67. doi: 10.2165/00003088-199222060-00004.