Schoofs G M, Willhite C C
J Appl Toxicol. 1984 Jun;4(3):141-4. doi: 10.1002/jat.2550040305.
Application software for economical and convenient calculation of median effective doses, confidence limits, potency ratios and slopes of quantal dose-response curves using a microcomputer is presented. The PASCAL language program is stored on diskette and it is compatible with many commercially available microcomputer systems. The program will simultaneously calculate the parameters for up to 20 different treatments and a total of 100 doses. Comparisons between the results of calculations of the LD50 of thiopental in mice using the PASCAL program, a modem-accessed commercially available probit analysis program and three, widely accepted manual calculation methods are made. The results of calculations of parallelism and the potency ratio between thiopental and phenobarbital-induced death in mice are shown.
本文介绍了一种应用软件，可使用微型计算机经济便捷地计算质反应剂量-反应曲线的半数有效剂量、置信限、效价比和斜率。该PASCAL语言程序存储在软盘上，与许多商用微型计算机系统兼容。该程序可同时计算多达20种不同处理和总共100个剂量的参数。对使用PASCAL程序、通过调制解调器访问的商用概率分析程序以及三种广泛接受的手工计算方法计算小鼠硫喷妥钠LD50的结果进行了比较。展示了小鼠硫喷妥钠和苯巴比妥诱导死亡之间的平行性和效价比的计算结果。
