Sas M, Godó G, Szöllósi J
Acta Med Hung. 1984;41(2-3):103-12.
Combined clomiphene + ethinyl-oestradiol therapy was applied to 103 women with functional infertility. Ovulatory responses were obtained with clomiphene in a number of cases, but no pregnancy ensued. Ethinyl-oestradiol was then administered in low doses together with clomiphene over 3 cycles until the day before the expected date of ovulation. This resulted in a further increase in the number of ovulatory cycles, and one-third of the women had become pregnant. Comparing the two types of treatment on the basis of quality, quantity and sperm-penetration of the cervical mucus, low doses of oestradiol were found to affect these parameters favourably. If the treatment is unsuccessful, i.e. if the parameters of mucus or of the conditions of penetration fail to respond, further investigations are required to find out whether a permanent damage to the cervical epithelium or some penetration disorder of immunological origin is responsible for the infertility.
对103名功能性不孕症女性应用克罗米芬 + 炔雌醇联合疗法。在一些病例中使用克罗米芬后出现了排卵反应，但未受孕。随后在3个周期内将炔雌醇与克罗米芬低剂量联合使用，直至预计排卵日前一天。这导致排卵周期数进一步增加，三分之一的女性怀孕。基于宫颈黏液的质量、数量和精子穿透能力对两种治疗方法进行比较，发现低剂量雌二醇对这些参数有有利影响。如果治疗不成功，即如果黏液参数或穿透条件没有反应，则需要进一步调查以确定宫颈上皮的永久性损伤或某些免疫源性穿透障碍是否是导致不孕的原因。
