Walton J C, Kaufmann J C
Arch Pathol Lab Med. 1984 Sep;108(9):755-6.
A recent publication described autopsy samples from five brains in which positive staining for iron was observed as surrounding demyelinated plaques. Because this has not been previously reported, autopsy material from 13 patients who were being followed up at the Multiple Sclerosis (MS) Clinic, University Hospital, The University of Western Ontario, London, Ontario, was reviewed. A total of 32 paraffin-embedded blocks containing demyelinated plaques of varying age were sectioned and stained using a standard acid ferrocyanide technique (Peris' test) for iron. Microscopic examination failed to detect the presence of significant positive staining either within or surrounding the areas of demyelination. Positive histochemical staining for iron identifies hemosiderin, the presence of which suggests either iron overload or remote hemorrhage. Support for these two processes in the pathogenesis of MS could not be provided from our material.
最近有一篇出版物描述了取自五个大脑的尸检样本，其中观察到铁染色阳性出现在脱髓鞘斑块周围。由于此前未曾有过此类报道，因此对安大略省伦敦市西安大略大学大学医院多发性硬化症（MS）诊所正在随访的13例患者的尸检材料进行了回顾。总共对32个含有不同年龄脱髓鞘斑块的石蜡包埋块进行切片，并使用标准酸性亚铁氰化物技术（佩里斯试验）对铁进行染色。显微镜检查未能在脱髓鞘区域内或其周围检测到明显的阳性染色。铁的阳性组织化学染色可识别含铁血黄素，其存在表明存在铁过载或既往出血。我们的材料无法为MS发病机制中的这两个过程提供支持。
