Kalra S P, Crowley W R
Life Sci. 1984 Sep 10;35(11):1173-6. doi: 10.1016/0024-3205(84)90187-5.
Neuropeptide Y, a recently isolated neuropeptide exhibited norepinephrine-like effects on LH release after intracerebroventricular administration at doses from 0.5 to 10 micrograms. While it promptly suppressed LH release in ovariectomized rats, there was a dose-related stimulation of LH secretion in ovarian steroid primed-ovariectomized rats. In view of the evidence that neuropeptide Y may coexist with adrenergic neurotransmitters, these findings suggest that it may play a role in regulation of LH release in the rat, either independently or in concert with catecholamines.
神经肽Y是一种最近分离出的神经肽，脑室内注射剂量为0.5至10微克时，对促黄体激素（LH）释放呈现出类似去甲肾上腺素的作用。虽然它能迅速抑制去卵巢大鼠的LH释放，但在卵巢类固醇预处理的去卵巢大鼠中，却存在剂量相关的LH分泌刺激作用。鉴于有证据表明神经肽Y可能与肾上腺素能神经递质共存，这些发现提示，它可能在大鼠LH释放的调节中发挥作用，无论是独立发挥作用还是与儿茶酚胺协同发挥作用。
