Miyazono K, Okazaki T, Uchida S, Totsuka Y, Matsumoto T, Ogata E, Terakawa K, Kurihara N, Takeda T
Arch Intern Med. 1984 Sep;144(9):1764-5.
Cough productive of sputum, exertional dyspnea, and hypoxemia developed in two patients with Graves' disease after six months (patient 1) or three weeks (patient 2) of treatment with propylthiouracil, 300 mg/day. Chest roentgenograms and transbronchial lung biopsy specimens revealed diffuse interstitial pneumonitis. Lymphocyte transformation by phytohemagglutinin was highly stimulated by propylthiouracil. Symptoms and signs improved after cessation of the drug therapy and administration of prednisolone acetate. These cases represent the first report of a complication of diffuse interstitial pneumonitis induced by propylthiouracil.
两名格雷夫斯病患者在接受每日300毫克丙硫氧嘧啶治疗6个月（患者1）或3周（患者2）后，出现了咳痰性咳嗽、劳力性呼吸困难和低氧血症。胸部X线片和经支气管肺活检标本显示为弥漫性间质性肺炎。丙硫氧嘧啶可高度刺激植物血凝素引起的淋巴细胞转化。停药并给予醋酸泼尼松龙后，症状和体征有所改善。这些病例是丙硫氧嘧啶诱发弥漫性间质性肺炎并发症的首例报道。
