Riou R, Duvillard P, Touraine R
Poumon Coeur. 1982;38(1):57-62.
Two patients with small cell carcinoma of the lung treated by chemoradiotherapy developed, diffuse interstitial pneumonitis after 7 and 21 months of treatment while in complete remission of their malignant disease. One patient died after an acute respiratory distress syndrome, but the second improved after steroid therapy and discontinuation of cytotoxic therapy. Pulmonary toxicity appeared to be related to cyclophosphamide therapy, but radiation therapy could have potentiated cyclophosphamide toxicity as it has been shown in bleomycin lung disease.
两名接受放化疗的小细胞肺癌患者在治疗7个月和21个月后，出现弥漫性间质性肺炎，此时其恶性疾病处于完全缓解状态。一名患者在急性呼吸窘迫综合征后死亡，但第二名患者在接受类固醇治疗并停用细胞毒性治疗后病情好转。肺毒性似乎与环磷酰胺治疗有关，但放疗可能增强了环磷酰胺的毒性，正如在博来霉素所致肺病中所显示的那样。
