Klöcking H P, Markwardt F, Hoffmann A
Biomed Biochim Acta. 1984;43(4):501-7.
In animal experiments the anabolic steroids 4-chloro-17 beta-hydroxy-17-methylandrosta-1,4-dien-3-one and 4-chloro-11 beta-hydroxy-17-methylandrosta-1,4-dien-3-one were tested for their ability to enhance fibrinolysis in comparison to stanozolol. After daily administration of 2 mg/kg for 12 weeks the anabolic steroids were found to enhance spontaneous fibrinolytic activity of blood, fibrinolytic capacity and tissue plasminogen activator activity in the kidneys of rats and rabbits. Concomitantly, the AT III activity of blood increased.
在动物实验中，对合成代谢类固醇4-氯-17β-羟基-17-甲基雄甾-1,4-二烯-3-酮和4-氯-11β-羟基-17-甲基雄甾-1,4-二烯-3-酮与司坦唑醇相比增强纤维蛋白溶解的能力进行了测试。在每天以2mg/kg的剂量给药12周后，发现这些合成代谢类固醇可增强大鼠和家兔血液的自发纤维蛋白溶解活性、纤维蛋白溶解能力以及肾脏中的组织纤溶酶原激活剂活性。同时，血液中的抗凝血酶III活性增加。
