合成代谢类固醇对血浆抗凝血酶III、α2巨球蛋白和α1抗胰蛋白酶水平的影响。
Effect of anabolic steroids on plasma antithrombin III. alpha2 macroglobulin and alpha1 antitrypsin levels.
作者信息
Walker I D, Davidson J F, Young P, Conkie J A
出版信息
Thromb Diath Haemorrh. 1975 Sep 30;34(1):106-14.
The effect of seven different anabolic steroids (Ethyloestrenol, Methenolone acetate, Norethandrolone, Methylandrostenediol, Oxymetholone, Methandienone, and Stanozolol) on three alpha-globulin antiprotease inhibitors of thrombin and plasmin was studied in men with ischaemic heart disease. In distinct contrast to the oral contraceptives, five of the six 17-alpha-alkylated anabolic steroids studied produced increased plasma Antithrombin III levels and five produced decreased levels of plasma alpha2-macroglobulin. The effect on plasma alpha1-antitrypsin levels was less clear-cut but three of the steroids examined produced significantly elevated levels. The increased plasma fibrinolytic activity which the 17-alpha-alkylated anabolic steroids induce is therefore unlikely to be secondary to disseminated intravascular coagulation.
在患有缺血性心脏病的男性中，研究了七种不同的合成代谢类固醇（乙基雌烯醇、乙酸美替诺龙、诺乙雄龙、甲基雄烯二醇、羟甲烯龙、美雄酮和司坦唑醇）对三种凝血酶和纤溶酶的α球蛋白抗蛋白酶抑制剂的影响。与口服避孕药形成鲜明对比的是，所研究的六种17-α-烷基化合成代谢类固醇中有五种使血浆抗凝血酶III水平升高，五种使血浆α2-巨球蛋白水平降低。对血浆α1-抗胰蛋白酶水平的影响不太明确，但所检测的三种类固醇使水平显著升高。因此，17-α-烷基化合成代谢类固醇诱导的血浆纤溶活性增加不太可能继发于弥散性血管内凝血。
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