Masini A, Trenti T, Ventura E, Ceccarelli-Stanzani D, Muscatello U
Biochem Biophys Res Commun. 1984 Oct 30;124(2):462-9. doi: 10.1016/0006-291x(84)91576-6.
The effect of in vivo hepatic iron overload, induced by two different amounts of iron, on the energy-transducing efficiency of the mitochondrial membrane has been examined. It has been found that when the epatic iron concentration is up to a threshold value mitochondria present an anomalous membrane potential. Addition of oligomycin fully restitutes it. A low content of intramitochondrial K+ is connected with this pathological condition. A relative lack of antioxidant capability is parallely exhibited by these mitochondria. A possible involvement of lipid peroxidation process in vivo in causing the membrane potential drop and the net efflux of intramitochondrial K+ is suggested.
研究了两种不同铁含量诱导的体内肝脏铁过载对线粒体膜能量转换效率的影响。结果发现，当肝脏铁浓度达到阈值时，线粒体呈现异常膜电位。加入寡霉素可使其完全恢复。线粒体内K+含量低与这种病理状态有关。这些线粒体同时表现出相对缺乏抗氧化能力。提示体内脂质过氧化过程可能参与导致膜电位下降和线粒体内K+的净外流。
