Studies on human fibronectin and liposomal encapsulated forms in rats and rabbits.

Human fibronectin as the free glycoprotein or in liposomal form was injected into rabbits and rats. Organ distribution, lifetimes and cell penetration were examined using radioactively marked material. A major difference is that liposomal fibronectin is largely concentrated in the lungs whereas most of the free protein is found in the liver. Fixation to human erythrocytes both washed and in total blood was also studied for both forms of fibronectin.