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外源性超氧化物歧化酶的细胞穿透作用。

Cell penetration by exogenous superoxide dismutase.

作者信息

Michelson A M, Puget K

出版信息

Acta Physiol Scand Suppl. 1980;492:67-80.

PMID:6939307
Abstract

The fixation and penetration of liposomal encapsulated dismutase (SOD) with human erythrocytes and other eucaryote cells is described. Such preparations not only facilitate fixation and penetration of the enzyme as a function of liposome composition, but also confer an increased physiological life time as well as a marked organ specificity. Such packed SOD could be useful for a pharmacological application of the enzyme.

摘要

描述了脂质体包裹的超氧化物歧化酶(SOD)与人红细胞及其他真核细胞的固定和渗透情况。这类制剂不仅根据脂质体组成促进酶的固定和渗透,还能延长其生理寿命并赋予显著的器官特异性。这种包装的超氧化物歧化酶对于该酶的药理学应用可能有用。

相似文献

1
Cell penetration by exogenous superoxide dismutase.外源性超氧化物歧化酶的细胞穿透作用。
Acta Physiol Scand Suppl. 1980;492:67-80.
2
[Medical aspects of superoxide dismutases].[超氧化物歧化酶的医学方面]
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3
Cellular penetration of fluorescently labeled superoxide dismutases of various origins.不同来源的荧光标记超氧化物歧化酶的细胞穿透情况。
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Oxygen radicals.氧自由基
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Liposomal superoxide dismutases and their use in the treatment of experimental arthritis.脂质体超氧化物歧化酶及其在实验性关节炎治疗中的应用。
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8
Immunocytochemical study of uptake of exogenous carrier-free copper-zinc superoxide dismutase by peripheral blood lymphocytes.外周血淋巴细胞对外源性无载体铜锌超氧化物歧化酶摄取的免疫细胞化学研究。
Cell Mol Biol (Noisy-le-grand). 1996 Dec;42(8):1137-43.
9
The effect of liposomes with superoxide dismutase on A2182 cells.含超氧化物歧化酶的脂质体对A2182细胞的作用。
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引用本文的文献

1
Recombinant human-type SOD attenuates circulatory disorders after reperfusion of splanchnic organs in rats.重组人型超氧化物歧化酶可减轻大鼠内脏器官再灌注后的循环障碍。
J Anesth. 1992 Jul;6(3):247-54. doi: 10.1007/s0054020060247.
2
Cellular penetration of fluorescently labeled superoxide dismutases of various origins.不同来源的荧光标记超氧化物歧化酶的细胞穿透情况。
Mol Med. 1999 Aug;5(8):517-25.
3
Superoxide-mediated clastogenesis and anticlastogenic effects of exogenous superoxide dismutase.超氧化物介导的断裂发生以及外源性超氧化物歧化酶的抗断裂作用
Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12799-804. doi: 10.1073/pnas.93.23.12799.
4
Clinical pharmacokinetics and delivery of bovine superoxide dismutase.牛超氧化物歧化酶的临床药代动力学与给药方式
Clin Pharmacokinet. 1995 Jan;28(1):17-25. doi: 10.2165/00003088-199528010-00003.
5
Cross-clamping of the thoracic aorta. Influence of aortic shunts, laminectomy, papaverine, calcium channel blocker, allopurinol, and superoxide dismutase on spinal cord blood flow and paraplegia in baboons.胸主动脉交叉钳夹。主动脉分流、椎板切除术、罂粟碱、钙通道阻滞剂、别嘌醇和超氧化物歧化酶对狒狒脊髓血流和截瘫的影响。
Ann Surg. 1986 Jul;204(1):38-47. doi: 10.1097/00000658-198607000-00005.
6
Superoxide dismutase protects cultured neurons against death by starvation.超氧化物歧化酶可保护培养的神经元免受饥饿导致的死亡。
Proc Natl Acad Sci U S A. 1987 May;84(9):3056-9. doi: 10.1073/pnas.84.9.3056.
7
Hydrogen peroxide mediates reperfusion injury in the isolated rat heart.过氧化氢介导离体大鼠心脏的再灌注损伤。
Mol Cell Biochem. 1988 Dec;84(2):173-5. doi: 10.1007/BF00421052.
8
Xanthine oxidase-derived hydrogen peroxide contributes to ischemia reperfusion-induced edema in gerbil brains.黄嘌呤氧化酶衍生的过氧化氢导致沙鼠脑缺血再灌注诱导的水肿。
J Clin Invest. 1988 May;81(5):1556-62. doi: 10.1172/JCI113488.
9
Role of hydrogen peroxide and hydroxyl radical formation in the killing of Ehrlich tumor cells by anticancer quinones.过氧化氢和羟基自由基的形成在抗癌醌类物质杀伤艾氏腹水癌细胞中的作用
Proc Natl Acad Sci U S A. 1986 Jun;83(12):4514-8. doi: 10.1073/pnas.83.12.4514.
10
Liposome-encapsulated superoxide dismutase prevents liver necrosis induced by acetaminophen.脂质体包裹的超氧化物歧化酶可预防对乙酰氨基酚诱导的肝坏死。
Am J Pathol. 1990 Apr;136(4):787-95.