Moussa M A
Comput Programs Biomed. 1984;18(3):173-9. doi: 10.1016/0010-468x(84)90049-7.
This paper deals with: (1) estimation of the optimum clinical trial size minimizing the total cost, given types I and II errors, alpha, beta and response rate difference, delta; (2) studying the test performance by calculating the operating characteristic curve in case of available fixed total cost; (3) mapping the future course of the patient recruitment plan by estimating recruitment rate and final intake based on enrollment to date; (4) projecting the recruitment duration and probability of achieving the contracted goal in case the recruitment rate is well established.
（1）在给定I型和II型错误、α、β以及反应率差异δ的情况下，估计使总成本最小化的最佳临床试验规模；（2）在有可用固定总成本的情况下，通过计算操作特征曲线来研究测试性能；（3）根据迄今的入组情况估计招募率和最终入组人数，从而规划患者招募计划的未来进程；（4）在招募率确定的情况下，预测招募持续时间和实现合同目标的概率。
