Bloch D A
Stat Med. 1986 Nov-Dec;5(6):663-7. doi: 10.1002/sim.4780050613.
This paper discusses the advantage of using repeated outcome measurements on subjects in a clinical trial. We choose the number of subjects and the number of repeated outcome measurements to minimize a given cost function so that the clinical trial has power (1-beta) for specified significance level alpha. An example illustrates the results and emphasizes the importance of study design and of critical evaluation of how one measures the study endpoint.
本文讨论了在临床试验中对受试者使用重复结局测量的优势。我们选择受试者数量和重复结局测量的次数，以使给定的成本函数最小化，从而使临床试验在指定的显著性水平α下具有检验效能（1-β）。一个例子说明了结果，并强调了研究设计以及对如何测量研究终点进行批判性评估的重要性。
