Yeh J K, Aloia J F
Miner Electrolyte Metab. 1984;10(6):398-403.
The effect of cortisone on jejunal active and passive phosphate transport was evaluated by the in situ intestinal loop technique using 1.2 and 50 mM concentrations of phosphate. Animals were divided into four groups: (1) intact, (2) hypophysectomized (HX), (3) HX plus cortisone, (4) HX plus 1,25-dihydroxyvitamin D3[1,25(OH)2D3]. The results of the experiment suggest that cortisone enhances jejunal phosphate absorption in HX rats through two mechanisms: (1) increased mucosal cell membrane permeability, (2) enhanced water movement, resulting in a rise of luminal phosphate concentration which favors the active and passive transport of phosphate. Stimulation of phosphate transport by cortisone is different from the unidirectional specific phosphate transport caused by 1,25(OH)2D3.
采用原位肠袢技术，使用1.2 mM和50 mM浓度的磷酸盐，评估可的松对空肠主动和被动磷酸盐转运的影响。将动物分为四组：(1) 完整组，(2) 垂体切除组（HX），(3) HX加可的松组，(4) HX加1,25 - 二羟维生素D3 [1,25(OH)2D3]组。实验结果表明，可的松通过两种机制增强HX大鼠空肠的磷酸盐吸收：(1) 增加黏膜细胞膜通透性，(2) 增强水的移动，导致肠腔磷酸盐浓度升高，有利于磷酸盐的主动和被动转运。可的松对磷酸盐转运的刺激不同于1,25(OH)2D3引起的单向特异性磷酸盐转运。
