Mann D M
Acta Neuropathol. 1978 May 24;42(2):149-51. doi: 10.1007/BF00690983.
We have shown that as the number of granulovacuolar bodies in affected pyramidal cells of the hippocampus increases so cytoplasmic RNA contant is reduced. Prior to its degeration, the nucleolus is increased in volume while that of the nucleus remains unchanged in size throughout. The effects of these degenerative changes are to bring about a progressive decline in the capacity for nerve cell function, leading eventually to the death of the cell.
我们已经表明，随着海马体中受影响的锥体细胞内颗粒空泡体数量的增加，细胞质RNA含量会减少。在其退化之前，核仁体积增大，而细胞核的大小在整个过程中保持不变。这些退化性变化的影响是导致神经细胞功能能力逐渐下降，最终导致细胞死亡。
