Vallat J M, Loubet R, Leboutet M J, Loubet A
Acta Neuropathol. 1978 May 24;42(2):153-6. doi: 10.1007/BF00690984.
This report presents the morphological character of iron deposits in muscle biopsies of three patients who have been suffering from secondary hemochromatosis. The granules observed by light microscopy and located either in the cytoplasm of macrophages or inside muscle fibres are illustrated in electron micrographs. In this study, Thiery's technic, which is a specific and very sensitive reaction, has been very useful to confirm by electron microscopy that these granules contain iron. Such a study in muscle appears to be unique. In our experience, accumulation of hemosiderin pigment in muscle does not seem to be specific of any disease but suggests that a hepatic biopsy must be done.
本报告呈现了三名继发性血色素沉着症患者肌肉活检中铁沉积的形态学特征。光镜下观察到的位于巨噬细胞胞质或肌纤维内部的颗粒在电子显微镜照片中有展示。在本研究中，蒂埃里技术是一种特异且非常敏感的反应，通过电子显微镜证实这些颗粒含铁，这一技术非常有用。肌肉方面的此类研究似乎是独一无二的。根据我们的经验，肌肉中含铁血黄素色素的积累似乎并非任何疾病所特有，但提示必须进行肝活检。
