Griggs R C, Markesbery W R, Bauman A W, Callerame M L
J Neurol Sci. 1975 Jun;25(2):153-63. doi: 10.1016/0022-510x(75)90137-9.
A 63-year old woman with Waldenström's macroglobulinemina of 5 years' duration developed disabling pain in her extremities. The patient had required frequent plasmapheresis and transfusion for treatment of hypervisosity. Muscle biopsy from 2 separate sites showed striking deposition of hemosiderin in macrophages surrounding small vessels and features of slight denervation. Immunofluorescence demonstrated IgM deposition in vessel walls. Perivascular hemosiderin deposition in muscle has not previously been desicribed and may reflect traansfusion-hemosiderosis in a patient with a dysglobulinemia.
一名患有5年瓦尔登斯特伦巨球蛋白血症的63岁女性出现了四肢致残性疼痛。该患者因高黏滞血症的治疗需要频繁进行血浆置换和输血。来自两个不同部位的肌肉活检显示，小血管周围的巨噬细胞中有明显的含铁血黄素沉积以及轻微失神经支配的特征。免疫荧光显示血管壁中有IgM沉积。肌肉血管周围的含铁血黄素沉积此前未见描述，可能反映了一名球蛋白异常血症患者的输血性含铁血黄素沉着症。
