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通过将抗生素掺入凝胶态囊泡增强两性霉素B的选择性：圆二色性和渗透性研究

Enhancement of amphotericin B selectivity by antibiotic incorporation into gel state vesicles. A circular dichroism and permeability study.

作者信息

Vertut-Croquin A, Bolard J, Gary-Bobo C M

出版信息

Biochem Biophys Res Commun. 1984 Nov 30;125(1):360-6. doi: 10.1016/s0006-291x(84)80376-9.

DOI:10.1016/s0006-291x(84)80376-9
PMID:6548911
Abstract

The permeability induced in cholesterol-or ergosterol-containing phospholipid vesicles by Amphotericin B incorporated into Dipalmitoyl Phosphatidylcholine vesicles has been studied in parallel with Circular Dichroism spectroscopy measurements. In our conditions, Amphotericin B is 5 to 10 times more selective to ergosterol- than to cholesterol-containing vesicles. Such a large difference is not observed when Amphotericin B is directly added to the vesicles suspension as its solution in organic solvent.

摘要

将两性霉素B掺入二棕榈酰磷脂酰胆碱囊泡中，对含胆固醇或麦角固醇的磷脂囊泡诱导的通透性进行了研究，并与圆二色光谱测量同时进行。在我们的实验条件下，两性霉素B对含麦角固醇的囊泡的选择性比对含胆固醇的囊泡高5至10倍。当将两性霉素B以其在有机溶剂中的溶液形式直接添加到囊泡悬浮液中时，未观察到如此大的差异。

相似文献

1
Enhancement of amphotericin B selectivity by antibiotic incorporation into gel state vesicles. A circular dichroism and permeability study.通过将抗生素掺入凝胶态囊泡增强两性霉素B的选择性：圆二色性和渗透性研究
Biochem Biophys Res Commun. 1984 Nov 30;125(1):360-6. doi: 10.1016/s0006-291x(84)80376-9.
2
Differences in the interaction of the polyene antibiotic amphotericin B with cholesterol- or ergosterol-containing phospholipid vesicles. A circular dichroism and permeability study.多烯抗生素两性霉素B与含胆固醇或麦角固醇的磷脂囊泡相互作用的差异。圆二色性和通透性研究。
Biochemistry. 1983 Jun 7;22(12):2939-44. doi: 10.1021/bi00281a024.
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Interaction of the polyene antibiotic etruscomycin with large unilamellar lipid vesicles: binding and proton permeability inducement.多烯抗生素埃特鲁霉素与大单层脂质囊泡的相互作用：结合与质子渗透性诱导
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Interaction of polyene antibiotics with membrane lipids: physicochemical studies of the molecular basis of selectivity.多烯抗生素与膜脂的相互作用：选择性分子基础的物理化学研究
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One-sided action of amphotericin B on cholesterol-containing membranes is determined by its self-association in the medium.两性霉素B对含胆固醇膜的单侧作用取决于其在介质中的自缔合。
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On the existence of an amphotericin B--sterol complex in lipid vesicles and in propanol-water systems.关于两性霉素B - 甾醇复合物在脂质囊泡和丙醇 - 水体系中的存在情况。
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Transfer of amphotericin B from gel state vesicles to mycoplasma cells: biphasic action on potassium transport and permeability.两性霉素B从凝胶态囊泡向支原体细胞的转移：对钾离子转运和通透性的双相作用
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Interaction between phospholipid bilayer membranes and the polyene antibiotic amphotericin B: lipid state and cholesterol content dependence.磷脂双分子层膜与多烯抗生素两性霉素B之间的相互作用：脂质状态和胆固醇含量依赖性
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A selective cholesterol-dependent induction of H+/OH- currents in phospholipid vesicles by amphotericin B.两性霉素B对磷脂囊泡中H⁺/OH⁻电流的选择性胆固醇依赖性诱导作用。
Biochemistry. 1988 Apr 19;27(8):2656-60. doi: 10.1021/bi00408a004.
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Association of the polyene antibiotic amphotericin B with phospholipid vesicles: perturbation by temperature changes.
Can J Biochem. 1982 Aug;60(8):782-9. doi: 10.1139/o82-097.

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Carrier effects on biological activity of amphotericin B.载体对两性霉素B生物活性的影响。
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Effects of elevation of serum cholesterol and administration of amphotericin B complexed to lipoproteins on amphotericin B-induced toxicity in rabbits.血清胆固醇升高及给予与脂蛋白复合的两性霉素B对兔两性霉素B诱导毒性的影响。
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Transfer of amphotericin B from gel state vesicles to mycoplasma cells: biphasic action on potassium transport and permeability.两性霉素B从凝胶态囊泡向支原体细胞的转移：对钾离子转运和通透性的双相作用
Antimicrob Agents Chemother. 1985 Aug;28(2):167-71. doi: 10.1128/AAC.28.2.167.