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1
Effects of elevation of serum cholesterol and administration of amphotericin B complexed to lipoproteins on amphotericin B-induced toxicity in rabbits.血清胆固醇升高及给予与脂蛋白复合的两性霉素B对兔两性霉素B诱导毒性的影响。
Antimicrob Agents Chemother. 1985 Jul;28(1):144-5. doi: 10.1128/AAC.28.1.144.
2
Treatment of experimental invasive aspergillosis with novel amphotericin B/cholesterol-sulfate complexes.新型两性霉素B/胆固醇硫酸酯复合物治疗实验性侵袭性曲霉病
J Infect Dis. 1989 Apr;159(4):717-24. doi: 10.1093/infdis/159.4.717.
3
In-vivo activity and tolerance of conventional formulation versus fat emulsion formulation of amphotericin B in experimental disseminated candidiasis in neutropenic rabbits.两性霉素B常规制剂与脂肪乳剂在中性粒细胞减少兔实验性播散性念珠菌病中的体内活性及耐受性比较
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4
Decreased toxicity of liposomal amphotericin B due to association of amphotericin B with high-density lipoproteins: role of lipid transfer protein.两性霉素B与高密度脂蛋白结合导致脂质体两性霉素B毒性降低：脂质转运蛋白的作用
J Pharm Sci. 1994 Jul;83(7):1006-10. doi: 10.1002/jps.2600830716.
5
Influence of diet on experimental toxicity of amphotericin B deoxycholate.饮食对两性霉素B脱氧胆酸盐实验毒性的影响。
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Amphotericin B toxicity as related to the formation of oxidatively modified low-density lipoproteins.两性霉素B毒性与氧化修饰低密度脂蛋白的形成相关。
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Immunization with cholesterol-rich liposomes induces anti-cholesterol antibodies and reduces diet-induced hypercholesterolemia and plaque formation.用富含胆固醇的脂质体进行免疫接种可诱导产生抗胆固醇抗体，并减少饮食诱导的高胆固醇血症和斑块形成。
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[Binding of the aromatic heptaen levorin and the nonaromatic heptaen amphotericin B with proteins and lipoproteins of the blood].[芳香族七烯类药物左菌素与非芳香族七烯类药物两性霉素B与血液中的蛋白质和脂蛋白的结合]
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Intracavernosal injections of vascular endothelial growth factor protects endothelial dependent corpora cavernosal smooth muscle relaxation in the hypercholesterolemic rabbit: a preliminary study.海绵体内注射血管内皮生长因子对高胆固醇血症兔海绵体平滑肌内皮依赖性舒张功能的保护作用：一项初步研究。
Int J Impot Res. 2000 Dec;12(6):334-9. doi: 10.1038/sj.ijir.3900621.
10
Preferential distribution of amphotericin B lipid complex into human HDL3 is a consequence of high density lipoprotein coat lipid content.两性霉素B脂质复合物在人HDL3中的优先分布是高密度脂蛋白外壳脂质含量的结果。
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Evaluation of Total Body Weight versus Adjusted Body Weight Liposomal Amphotericin B Dosing in Obese Patients.评估肥胖患者全身体重与调整后体重的脂质体两性霉素 B 剂量。
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Rat and rabbit plasma distribution of free and chylomicron-associated BIRT 377, a novel small molecule antagonist of LFA-1-mediated cell adhesion.新型LFA-1介导的细胞黏附小分子拮抗剂BIRT 377在大鼠和兔血浆中的游离及与乳糜微粒相关的分布情况
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Species differences in the proportion of plasma lipoprotein lipid carried by high-density lipoproteins influence the distribution of free and liposomal nystatin in human, dog, and rat plasma.高密度脂蛋白所携带的血浆脂蛋白脂质比例的种属差异，会影响制霉菌素游离型及脂质体在人、犬和大鼠血浆中的分布。
Antimicrob Agents Chemother. 1999 Jun;43(6):1424-8. doi: 10.1128/AAC.43.6.1424.
4
Effect of fasting on temporal variation in the nephrotoxicity of amphotericin B in rats.禁食对两性霉素B肾毒性在大鼠体内时间变化的影响。
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Differences in the lipoprotein distribution of free and liposome-associated all-trans-retinoic acid in human, dog, and rat plasma are due to variations in lipoprotein lipid and protein content.人、犬和大鼠血浆中游离及脂质体结合的全反式维甲酸脂蛋白分布的差异是由于脂蛋白脂质和蛋白质含量的变化所致。
Antimicrob Agents Chemother. 1998 Jul;42(7):1646-53. doi: 10.1128/AAC.42.7.1646.
6
Physical characteristics and lipoprotein distribution of liposomal nystatin in human plasma.制霉菌素脂质体在人血浆中的物理特性及脂蛋白分布
Antimicrob Agents Chemother. 1997 Sep;41(9):1871-5. doi: 10.1128/AAC.41.9.1871.
7
Carrier effects on biological activity of amphotericin B.载体对两性霉素B生物活性的影响。
Clin Microbiol Rev. 1996 Oct;9(4):512-31. doi: 10.1128/CMR.9.4.512.
8
Roles of liposome composition and temperature in distribution of amphotericin B in serum lipoproteins.脂质体组成和温度在两性霉素B于血清脂蛋白中分布的作用。
Antimicrob Agents Chemother. 1993 Feb;37(2):246-50. doi: 10.1128/AAC.37.2.246.
9
Amphotericin B incorporated into egg lecithin-bile salt mixed micelles: molecular and cellular aspects relevant to therapeutic efficacy in experimental mycoses.两性霉素B掺入卵磷脂-胆盐混合胶束：与实验性真菌病治疗效果相关的分子和细胞方面
Antimicrob Agents Chemother. 1994 Feb;38(2):300-6. doi: 10.1128/AAC.38.2.300.
10
Influence of diet on experimental toxicity of amphotericin B deoxycholate.饮食对两性霉素B脱氧胆酸盐实验毒性的影响。
Antimicrob Agents Chemother. 1994 May;38(5):963-8. doi: 10.1128/AAC.38.5.963.

本文引用的文献

1
Treatment and prophylaxis of disseminated infection due to Candida albicans in mice with liposome-encapsulated amphotericin B.脂质体包裹两性霉素B对小鼠白色念珠菌播散感染的治疗与预防
J Infect Dis. 1983 May;147(5):939-45. doi: 10.1093/infdis/147.5.939.
2
Dissociation kinetics and equilibrium binding properties of polyene antibiotic complexes with phosphatidylcholine/sterol vesicles.多烯抗生素复合物与磷脂酰胆碱/甾醇囊泡的解离动力学及平衡结合特性
Biochemistry. 1984 Apr 10;23(8):1668-74. doi: 10.1021/bi00303a014.
3
Enhancement of amphotericin B selectivity by antibiotic incorporation into gel state vesicles. A circular dichroism and permeability study.通过将抗生素掺入凝胶态囊泡增强两性霉素B的选择性：圆二色性和渗透性研究
Biochem Biophys Res Commun. 1984 Nov 30;125(1):360-6. doi: 10.1016/s0006-291x(84)80376-9.
4
Interaction of plasma proteins and lipoproteins with amphotericin B.血浆蛋白和脂蛋白与两性霉素B的相互作用。
J Infect Dis. 1984 Jun;149(6):986-97. doi: 10.1093/infdis/149.6.986.
5
Antifungal agents useful in therapy of systemic fungal infections.可用于全身性真菌感染治疗的抗真菌药物。
Annu Rev Pharmacol Toxicol. 1983;23:303-30. doi: 10.1146/annurev.pa.23.040183.001511.
6
A pharmacologic guide to the clinical use of amphotericin B.两性霉素B临床应用的药理学指南
J Infect Dis. 1969 Oct;120(4):427-36. doi: 10.1093/infdis/120.4.427.
7
Enzymatic determination of total serum cholesterol.血清总胆固醇的酶法测定
Clin Chem. 1974 Apr;20(4):470-5.
8
Changes in apolipoproteins and properties of rabbit very low density lipoproteins on induction of cholesteremia.高胆固醇血症诱导下兔极低密度脂蛋白载脂蛋白及性质的变化
Biochemistry. 1974 Apr 9;13(8):1579-85. doi: 10.1021/bi00705a004.

血清胆固醇升高及给予与脂蛋白复合的两性霉素B对兔两性霉素B诱导毒性的影响。

Effects of elevation of serum cholesterol and administration of amphotericin B complexed to lipoproteins on amphotericin B-induced toxicity in rabbits.

作者信息

Koldin M H, Kobayashi G S, Brajtburg J, Medoff G

出版信息

Antimicrob Agents Chemother. 1985 Jul;28(1):144-5. doi: 10.1128/AAC.28.1.144.

DOI:10.1128/AAC.28.1.144
PMID:4037773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC176327/
Abstract

Amphotericin B was infused into normal rabbits or rabbits made hypercholesterolemic by diet. There was no difference in amphotericin B-induced toxicity between these two groups. Amphotericin B given in a mixture with human low-density lipoproteins was more toxic than when given without lipoproteins.

摘要

两性霉素B被注入正常兔子或通过饮食使其高胆固醇血症的兔子体内。这两组之间两性霉素B诱导的毒性没有差异。与人类低密度脂蛋白混合给予的两性霉素B比不与脂蛋白一起给予时毒性更大。