血清胆固醇升高及给予与脂蛋白复合的两性霉素B对兔两性霉素B诱导毒性的影响。
Effects of elevation of serum cholesterol and administration of amphotericin B complexed to lipoproteins on amphotericin B-induced toxicity in rabbits.
作者信息
Koldin M H, Kobayashi G S, Brajtburg J, Medoff G
出版信息
Antimicrob Agents Chemother. 1985 Jul;28(1):144-5. doi: 10.1128/AAC.28.1.144.
Abstract
Amphotericin B was infused into normal rabbits or rabbits made hypercholesterolemic by diet. There was no difference in amphotericin B-induced toxicity between these two groups. Amphotericin B given in a mixture with human low-density lipoproteins was more toxic than when given without lipoproteins.
摘要
两性霉素B被注入正常兔子或通过饮食使其高胆固醇血症的兔子体内。这两组之间两性霉素B诱导的毒性没有差异。与人类低密度脂蛋白混合给予的两性霉素B比不与脂蛋白一起给予时毒性更大。
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