Koller M E, Romslo I, Finne P H, Brockmeier F, Tyssebotn I
Acta Paediatr Scand. 1978 May;67(3):361-6. doi: 10.1111/j.1651-2227.1978.tb16335.x.
Free erythrocyte protoporphyrin (FEP) and serum ferritin have been determined in 57 healthy children and in 25 children with varying degrees of iron deficiency. FEP was found to be inversely correlated to the concentration of hemoglobin (r = -0.80) as well as to serum ferritin (r=-0.64). Elevated FEP was found in children with hemoglobin less than 12.5 g/dl, or serum ferritin less than 8 microgram/l. In a group of apparently hematologically normal children between the age of 10--14 years (hemoglobin greater than 12.5 g/dl), a 2-month-trial of iron medication resulted in an increase in hemoglobin and ferritin, and a decrease in FEP, indicating suboptimal supply of iron for hemoglobin synthesis before iron medication. In a patient with iron deficiency (FEP 15.3 mumole/l, hemoglobin 5.2 g/dl), iron therapy was followed by a rapid fall in FEP before any changes in hemoglobin, serum iron transferrin saturation and ferritin could be detected. The rapid fall in FEP during start of treatment in iron deficiency makes FEP a sensitive biochemical parameter on iron homeostasis in iron deficiency anemia.
对57名健康儿童和25名不同程度缺铁的儿童测定了游离红细胞原卟啉（FEP）和血清铁蛋白。发现FEP与血红蛋白浓度呈负相关（r = -0.80），也与血清铁蛋白呈负相关（r = -0.64）。血红蛋白低于12.5 g/dl或血清铁蛋白低于8微克/升的儿童中发现FEP升高。在一组年龄在10至14岁之间血液学上明显正常的儿童（血红蛋白大于12.5 g/dl）中，进行为期2个月的铁剂治疗试验后，血红蛋白和铁蛋白增加，FEP降低，表明在服用铁剂之前，用于血红蛋白合成的铁供应不足。在一名缺铁患者（FEP 15.3微摩尔/升，血红蛋白5.2 g/dl）中，铁剂治疗后FEP迅速下降，而此时血红蛋白、血清铁转铁蛋白饱和度和铁蛋白尚未出现任何变化。缺铁性贫血患者开始治疗时FEP迅速下降，这使得FEP成为缺铁性贫血中铁稳态的一个敏感生化指标。
