Thakker K M
Biopharm Drug Dispos. 1984 Oct-Dec;5(4):315-33. doi: 10.1002/bdd.2510050404.
The use of the electrical circuit simulation program SPICE2 for performing digital computer simulations of linear and non-linear pharmacokinetic-pharmacodynamic models is described. SPICE2 utilizes the principles of network thermodynamics (thermodynamics of electrical circuits). These principles dictate analogy between the conservation laws of chemical reactions and mass transport and Kirchhoff's laws of current and voltage balance, and also prove that Fick's law of diffusion is isomorphous with the conductance form of Ohm's law. Detailed descriptions of program inputs, formats, and options for simulation of linear and non-linear pharmacokinetic-pharmacodynamic systems are provided, with appropriate examples. Single as well as multiple dose simulations (accumulation kinetics and dynamics) are discussed. The advantages of SPICE2 over other available simulation packages, including user-friendliness, ease of operation, versatility, power, and the economy of time and effort afforded, are emphasized. The educational value of SPICE2 as a highly versatile tool for teaching both fundamental and complex pharmacokinetic-pharmacodynamic concepts, as well as its routine usage in elucidating complex research problems, are also discussed.
本文描述了使用电路模拟程序SPICE2对线性和非线性药代动力学-药效学模型进行数字计算机模拟的方法。SPICE2运用网络热力学原理（电路热力学）。这些原理规定了化学反应和质量传输的守恒定律与基尔霍夫电流和电压平衡定律之间的类比关系，并且还证明了菲克扩散定律与欧姆定律的电导形式同构。文中提供了线性和非线性药代动力学-药效学系统模拟的程序输入、格式及选项的详细说明，并配有适当的示例。讨论了单剂量和多剂量模拟（蓄积动力学和动态学）。强调了SPICE2相对于其他现有模拟软件包的优势，包括用户友好性、操作简便性、多功能性、强大功能以及所节省的时间和精力。还讨论了SPICE2作为一种极具通用性的工具在教授基础和复杂药代动力学-药效学概念方面的教育价值，以及它在阐明复杂研究问题中的常规用途。
