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Use of the circuit simulation program SPICE2 for analysis of the metabolism of anticancer drugs.

作者信息

White J C

出版信息

Bull Math Biol. 1986;48(3-4):353-80. doi: 10.1007/BF02459687.

DOI:10.1007/BF02459687
PMID:3828563
Abstract
摘要

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Use of the circuit simulation program SPICE2 for analysis of the metabolism of anticancer drugs.
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本文引用的文献

1
Correlation of cytotoxicity with incorporation of ara-C into DNA.细胞毒性与阿糖胞苷掺入DNA的相关性。
J Biol Chem. 1980 Oct 10;255(19):8997-900.
2
The relation between local and global transport parameters in an epithelial membrane having an asymmetric transport mechanism.具有不对称转运机制的上皮细胞膜中局部和整体转运参数之间的关系。
J Theor Biol. 1981 Feb 7;88(3):575-87. doi: 10.1016/0022-5193(81)90284-8.
3
Tight binding inhibitors--IX. Kinetic parameters of dihydrofolate reductase inhibited by methotrexate, an example of equilibrium study.紧密结合抑制剂——IX. 甲氨蝶呤抑制二氢叶酸还原酶的动力学参数，平衡研究实例。
Biochem Pharmacol. 1981 Jun 15;30(12):1507-15. doi: 10.1016/0006-2952(81)90374-9.
4
Methotrexate resistance in al L1210 cell line resulting from increased dihydrofolate reductase, decreased thymidylate synthetase activity, and normal membrane transport. Computer simulations based on network thermodynamics.由于二氢叶酸还原酶增加、胸苷酸合成酶活性降低以及正常的膜转运导致的L1210细胞系中甲氨蝶呤耐药性。基于网络热力学的计算机模拟。
J Biol Chem. 1981 Jun 10;256(11):5722-7.
5
A network thermodynamic model of glomerular dynamics: application in the rat.肾小球动力学的网络热力学模型：在大鼠中的应用
Kidney Int. 1981 Feb;19(2):359-73. doi: 10.1038/ki.1981.27.
6
Kinetic simulation of anticancer drug interactions.抗癌药物相互作用的动力学模拟
Int J Biomed Comput. 1980 May;11(3):197-224. doi: 10.1016/0020-7101(80)90045-8.
7
An analysis of glomerular dynamics in rat, dog, and man.大鼠、犬和人类肾小球动力学分析。
Kidney Int. 1982 Aug;22(2):136-45. doi: 10.1038/ki.1982.145.
8
Dynamic simulation of pharmacokinetic systems using the electrical circuit analysis program SPICE2.使用电路分析程序SPICE2对药代动力学系统进行动态模拟。
Comput Programs Biomed. 1982 Aug;15(1):61-72. doi: 10.1016/0010-468x(82)90056-3.
9
Pharmacokinetics of continuous intravenous and subcutaneous infusions of cytosine arabinoside.
Blood. 1982 Jun;59(6):1351-3.
10
Application of network thermodynamics to the computer modeling of the pharmacology of anticancer agents: a network model for methotrexate action as a comprehensive example.
Pharmacol Ther. 1981;15(2):251-91. doi: 10.1016/0163-7258(81)90045-0.