Samama M, Conard J, Horellou M H, Veuillet-Duval A, Lefrére J J
J Mal Vasc. 1984;9(4):321-5.
Important recent advances in the field of the biology of recurrent venous thrombosis include greater understanding of congenital deficiency states involving antithrombin III (AT III) and protein C. Other disturbances demonstrated were related to fibrinolysis frequently, and rarely platelet function and coagulation factors. Possible existence of these anomalies requires investigation during biologic tests in cases of recurrent venous thrombosis, particularly in the presence of a family history or onset of the initial affection before 40 years of age. Confirmation of the importance of screening for such anomalies is supplied by results of a study of 11 families with antithrombin III deficiency and 9 families deficients in protein C, and a literature review of cases. However, currently available biologic tests provide data enabling only partial explanation of the mechanism underlying recurrent venous thrombosis accidents.
复发性静脉血栓形成生物学领域最近的重要进展包括对涉及抗凝血酶III（AT III）和蛋白C的先天性缺陷状态有了更深入的了解。其他已证实的紊乱情况常常与纤维蛋白溶解有关，而与血小板功能和凝血因子有关的情况则很少见。在复发性静脉血栓形成病例的生物学检测过程中，特别是在有家族病史或在40岁之前首次发病的情况下，需要对这些异常情况的可能存在进行调查。对11个抗凝血酶III缺乏家族和9个蛋白C缺乏家族的研究结果以及对病例的文献综述，证实了筛查此类异常情况的重要性。然而，目前可用的生物学检测所提供的数据仅能部分解释复发性静脉血栓形成事件背后的机制。
