Viganò S, Mannucci P M, D'Angelo A, Gelfi C, Gensini G F, Rostagno C, Neri Serneri G G
Thromb Haemost. 1984 Dec 29;52(3):263-6.
Protein C, an antithrombotic protein, was measured immunologically in 299 patients with clinical conditions associated with a high frequency of venous or arterial thromboembolism. The mean protein C antigen (PC:Ag) level was high for 48 patients with ischemic heart disease and, to a lesser extent, for 95 diabetics. In 28 patients with thrombotic strokes, 48 patients with proximal deep-vein thrombosis and in 80 patients with localized or metastatic tumors, mean PC:Ag was normal. Comparison of the pattern of changes of PC:Ag levels with those of fibrinogen, orosomucoid and prothrombin in 21 patients during the postoperative period and in 20 patients with active rheumatoid arthritis ruled out the possibility that high PC:Ag is non-specific, acute-phase reaction to inflammation, tissue injury or neoplastic growth. Therefore, high PC:Ag might be specifically related to the thrombotic tendency of these patients, but the mechanism of such a relationship remains to be clarified.
蛋白C是一种抗血栓形成蛋白，对299例有静脉或动脉血栓栓塞高发病风险临床症状的患者进行了蛋白C的免疫检测。48例缺血性心脏病患者的平均蛋白C抗原（PC:Ag）水平较高，95例糖尿病患者的该水平略低。28例血栓性中风患者、48例近端深静脉血栓形成患者以及80例局部或转移性肿瘤患者的平均PC:Ag水平正常。对21例术后患者和20例活动性类风湿关节炎患者的PC:Ag水平变化模式与纤维蛋白原、血清类黏蛋白和凝血酶原的变化模式进行比较，排除了高PC:Ag是对炎症、组织损伤或肿瘤生长的非特异性急性期反应的可能性。因此，高PC:Ag可能与这些患者的血栓形成倾向有特定关系，但这种关系的机制仍有待阐明。
