哌仑西平对胃的细胞保护作用不是由儿茶酚胺介导的。

Gastric cytoprotection by pirenzepine is not mediated by catecholamines.

作者信息

Martinotti E, Bernardini C, Del Tacca M, Pellegrini M, Soldani G, Bertelli A

出版信息

Acta Physiol Hung. 1984;64(3-4):219-24.

Abstract

The effects of pirenzepine (in a dose of 25.0 mg X kg-1) and atropine (2.5 mg X kg-1) were studied on the development of gastric ulceration produced by pylorus ligation, polymyxin B and absolute ethanol, as well as on the gastric secretory responses and plasma level of noradrenaline. It was found that: (1) pirenzepine significantly decreased the development of ulcer formation produced by pylorus ligation, polymyxin B and absolute ethanol without any antisecretory response; (2) atropine inhibited gastric acid secretion, but no effect was obtained on ulcus produced by pylorus ligation, polymyxin B and absolute ethanol; (3) the plasma level of noradrenaline could be decreased by atropine and pirenzepine, although the difference did not reach statistical significance. It has been concluded that catecholamines are not involved in the gastric cytoprotective mechanism of pirenzepine.

摘要

研究了哌仑西平（剂量为25.0毫克/千克）和阿托品（2.5毫克/千克）对幽门结扎、多粘菌素B和无水乙醇所致胃溃疡形成的影响，以及对胃分泌反应和去甲肾上腺素血浆水平的影响。结果发现：（1）哌仑西平显著减少幽门结扎、多粘菌素B和无水乙醇所致溃疡形成的发展，且无任何抗分泌反应；（2）阿托品抑制胃酸分泌，但对幽门结扎、多粘菌素B和无水乙醇所致溃疡无作用；（3）阿托品和哌仑西平可降低去甲肾上腺素血浆水平，尽管差异未达到统计学显著性。得出的结论是，儿茶酚胺不参与哌仑西平的胃细胞保护机制。