Reversible acute renal failure due to monthly administration of rifampicin in a leprosy patient.

Special complications due to intermittent rifampicin administration have been well documented, specially for the treatment of tuberculosis. Multi-drug therapy recommended for the treatment of leprosy by W.H.O. (1982) advocates the administration of rifampicin at monthly interval and at this level of infrequent administration, complications linked with intermittent therapy are seldom noted. An adult male put on W.H.O. regimen for the treatment of lepromatous leprosy developed acute renal failure at the time of second and third monthly doses of rifampicin therapy, but recovered completely due to prompt treatment.