Damon E G, Mokler B V, Jones R K
Toxicol Appl Pharmacol. 1983 Mar 15;67(3):322-30. doi: 10.1016/0041-008x(83)90315-0.
The purpose of this study was to assess the effects of elastase-induced pulmonary emphysema and the inhalation of an irritant aerosol (Triton X-100, a nonionic surfactant similar to those used in a number of pressurized consumer products) on pulmonary deposition and retention of an insoluble test aerosol, 59Fe-labeled Fe2O3. Untreated rats or rats pretreated by intratracheal instillation with elastase were exposed to an aerosol of 59Fe-labeled Fe2O3 either 18 hr or 7 days after exposure to aerosolized Triton X-100 which was administered in doses of 20, 100, or 200 micrograms/g of lung. Rats pretreated with elastase had significantly lower pulmonary deposition of 59Fe than the untreated controls (p less than 0.005). Pulmonary deposition of Fe2O3 was unaffected by pretreatment with Triton X-100. Elastase treatment alone had no effect on retention of Fe2O3. Triton X-100 administered 18 hr prior to exposure of rats to Fe2O3 aerosol resulted in dose-related increases in whole-body retention of 59Fe. When rats were exposed to Triton X-100 7 days before exposure to Fe2O3, increased retention of 59Fe was noted only in those treated at the highest Triton X-100 dose level (200 micrograms/g).
本研究的目的是评估弹性蛋白酶诱导的肺气肿以及吸入刺激性气雾剂（Triton X-100，一种与许多加压消费品中使用的非离子表面活性剂类似的物质）对不溶性测试气雾剂59Fe标记的Fe2O3在肺部沉积和滞留的影响。未处理的大鼠或经气管内滴注弹性蛋白酶预处理的大鼠，在暴露于剂量为20、100或200微克/克肺的雾化Triton X-100后18小时或7天，暴露于59Fe标记的Fe2O3气雾剂中。用弹性蛋白酶预处理的大鼠肺部59Fe的沉积明显低于未处理的对照组（p<0.005）。Triton X-100预处理对Fe2O3的肺部沉积没有影响。单独使用弹性蛋白酶处理对Fe2O3的滞留没有影响。在大鼠暴露于Fe2O3气雾剂前18小时给予Triton X-100导致59Fe全身滞留量呈剂量相关增加。当大鼠在暴露于Fe2O3前7天暴露于Triton X-100时，仅在最高Triton X-100剂量水平（200微克/克）处理的大鼠中观察到59Fe滞留增加。
