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Multiple sclerosis: immunogenetic analyses of sib-pair double case families. II. Studies on the association of multiple sclerosis with C2, C4, BF, C3, C6, and GLO polymorphisms.

作者信息

Schröder R, Zander H, Andreas A, Mauff G

出版信息

Immunobiology. 1983 Mar;164(2):160-70. doi: 10.1016/S0171-2985(83)80007-2.

DOI:10.1016/S0171-2985(83)80007-2
PMID:6552216
Abstract

The complement component polymorphisms of C2, C4, BF, C3, C6, and the enzyme polymorphism GLO were studied in 13 sib-pair double case families with multiple sclerosis. A significant association was seen between MS patients and the C4 haplotype A4,B2 as compared with their healthy siblings. This finding seems to parallel reports on C2 hypocomplementemia in MS patients since C4 A4,B2 in normal individuals was also seen to be in linkage disequilibrium with the C2 deficiency allele (C2QO) by other investigators.

摘要

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Human C4 polymorphism: pedigree analysis of qualitative, quantitative, and functional parameters as a basis for phenotype interpretations.
人类C4多态性：定性、定量和功能参数的系谱分析作为表型解释的基础。
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Ann Rheum Dis. 1986 Jun;45(6):464-74. doi: 10.1136/ard.45.6.464.
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The mystery of the origin of multiple sclerosis.多发性硬化症的起源之谜。
J Neurol Neurosurg Psychiatry. 1986 Feb;49(2):113-23. doi: 10.1136/jnnp.49.2.113.