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慢性低氧血症患者迷走神经节和颈动脉体副神经节增生

Hyperplasia of vagal and carotid body paraganglia in patients with chronic hypoxemia.

作者信息

Lack E E

出版信息

Am J Pathol. 1978 Jun;91(3):497-516.

PMID:655261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2018321/
Abstract

Vagal and carotid body paraganglia were obtained from 43 randomly selected autopsies performed at the National Naval Medical Center. In each case, tissue from both sides was step sectioned and comparatively studied. The mean combined weight of carotid bodies in 37 control patients was 25.9 mg. There was good correlation between size and number of separate paraganglia comprising the vagal body (seven left, six right). Lobules were closely related to the ganglion nodosum and were actually within it in three instances. Tissue resembling parathyroid was encountered within 4 of the 86 resected vagus nerves. Lymphocytic infiltration occurred in carotid and vagal body paraganglia of 28% and 16% of patients, respectively. There was Schwann cell proliferatation in carotid body lobules of 2 patients; in another patient, talc emboli were present. The mean combined weight of carotid bodies in 6 patients with chronic hypoxemia was 47.6 mg, significantly greater than in the control group; in each case, lobules were enlarged. Chief cell hyperplasia occurred in vagal body paraganglia of 2 patients; in two other patients, lobules were large with equal proliferation of constituent cells. These morphologic findings indicate that in patients with chronic hypoxemia some vagal body paraganglia can be ascribed a chemoreceptor role similar to but probably less important than that of the carotid body.

摘要

迷走神经节和颈动脉体副神经节取自国家海军医疗中心随机选取的43例尸检样本。每例均对双侧组织进行连续切片并进行对比研究。37例对照患者的颈动脉体平均总重量为25.9毫克。构成迷走神经节的单个副神经节的大小和数量之间存在良好的相关性（左侧7个，右侧6个）。小叶与结节神经节密切相关，有3例实际上位于结节神经节内。在86条切除的迷走神经中有4条发现了类似甲状旁腺的组织。分别有28%和16%的患者的颈动脉体副神经节和迷走神经节出现淋巴细胞浸润。2例患者的颈动脉体小叶出现施万细胞增殖；另1例患者存在滑石粉栓子。6例慢性低氧血症患者的颈动脉体平均总重量为47.6毫克，显著高于对照组；每例患者的小叶均增大。2例患者的迷走神经节副神经节出现主细胞增生；另外2例患者的小叶较大，组成细胞增殖程度相同。这些形态学发现表明，在慢性低氧血症患者中，一些迷走神经节副神经节可发挥与颈动脉体类似但可能重要性稍低的化学感受器作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b92/2018321/f14e140c0740/amjpathol00740-0107-b.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b92/2018321/fc97b6c2d33d/amjpathol00740-0103-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b92/2018321/95e9e9d9ada9/amjpathol00740-0104-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b92/2018321/566d661e8782/amjpathol00740-0104-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b92/2018321/d2f15252131f/amjpathol00740-0105-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b92/2018321/4aa45afb165f/amjpathol00740-0105-b.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b92/2018321/f14e140c0740/amjpathol00740-0107-b.jpg

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Nonchromaffin paraganglioma of ganglion nodosum, carotid body, and aortic-arch bodies.结节状神经节、颈动脉体和主动脉弓体的非嗜铬性副神经节瘤。
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