Arias-Stella J, Valcarcel J
Hum Pathol. 1976 Jul;7(4):361-73. doi: 10.1016/s0046-8177(76)80052-4.
The area occupied by parenchymal cells, in sections comprising the entire half of the surface of the carotid body, is significantly greater in people born and living at 14,350 feet than in those at sea level. The enlargement and increase in weight of the carotid bodies observed at high altitudes can thus be attributed to hyperplasia of parenchymal tissue. The proliferated cells have the morphology of type I chief cells and display marked vacuolation and depletion of yellow-green, naturally fluorescing, bioamine containing granules. Although unimportant variations in size and weight in relation to age occurred at sea level, it was found that the magnitude of the carotid body enlargement increased with age at high altitudes. The augmented carotid body size and weight in relation to age at high altitudes are associated with progressive chemoreceptor insensitivity. The physiologic and pathologic significance of these findings is discussed.
在包含颈动脉体整个表面一半的切片中，出生并生活在海拔14350英尺处的人的实质细胞所占面积，比海平面处的人显著更大。因此，在高海拔地区观察到的颈动脉体增大和重量增加可归因于实质组织的增生。增殖的细胞具有I型主细胞的形态，并表现出明显的空泡化以及黄绿色、天然荧光、含生物胺颗粒的减少。虽然在海平面处，颈动脉体大小和重量随年龄有不重要的变化，但发现在高海拔地区，颈动脉体增大的幅度随年龄增加。高海拔地区与年龄相关的颈动脉体大小和重量增加与化学感受器的渐进性不敏感有关。讨论了这些发现的生理和病理意义。
