Gummerus M
Geburtshilfe Frauenheilkd. 1983 Mar;43(3):151-5. doi: 10.1055/s-2008-1037077.
140 patients with a threatening premature birth at the greater than or equal to 24-less than 37 week of gestation were in this study randomly treated with hexoprenalin or salbutamol. In 77% in the hexoprenalin and in 74% in the salbutamol group the weight of the newborn was greater than or equal to 2500 g. In 66% in both study groups the birth occurred after the completed 37 weeks of gestation. During infusion of hexoprenalin tachycardia in mothers occurred statistically highly significantly less than during salbutamol. 11% of the mothers in the hexoprenalin group had side-effects during infusion compared to 30% in the salbutamol group. The correlation between the tocolysis-index (Baumgarten) and the prolongation-index (Richter) given by the regression lines facilitates in some measure the comparison of different tocolytic drugs concerning its tocolytic effect.
本研究将140例孕24周及以上至小于37周有早产风险的患者随机分为两组,分别接受海索那林或沙丁胺醇治疗。海索那林组77%的新生儿体重≥2500克,沙丁胺醇组为74%。两个研究组中均有66%的患者在妊娠满37周后分娩。与使用沙丁胺醇相比,使用海索那林期间母亲出现心动过速的情况在统计学上显著减少。海索那林组11%的母亲在输注过程中有副作用,而沙丁胺醇组为30%。回归线给出的宫缩抑制指数(鲍姆加滕)和延长指数(里希特)之间的相关性在一定程度上便于比较不同宫缩抑制药物的宫缩抑制效果。