Nichols E G, Barstow R E, Cooper D
Nurs Res. 1983 Jul-Aug;32(4):247-52.
Using stratified random sampling, 130 patients from three hospital units were assigned to three treatment groups to test the relationship between the frequency of changing intravenous (IV) tubing and percutaneous sites and the incidence of phlebitis. Measures of pain, skin temperature, and erythema were collected every 12 hours. Chi-square analysis indicated there were no significant differences in rates of phlebitis whether the tubings were changed every 24 hours or 48 hours. Further, there were no significant differences in the incidence of phlebitis between 48- and 72-hour site change groups. Clinically, subjects in the 24-hour tubing change groups had lower rates of phlebitis. Analysis of the relationship of other factors such as environment, IV medication (heparin, potassium chloride, antibiotics, and corticosteroids), diagnosis, and age showed no statistically significant relationships. It was concluded that more frequent tubing changes are not harmful to subjects and, in fact, may be beneficial.
采用分层随机抽样法，从三个医院科室选取130名患者，将其分为三个治疗组，以检验更换静脉输液管和经皮穿刺部位的频率与静脉炎发生率之间的关系。每12小时收集疼痛、皮肤温度和红斑的测量数据。卡方分析表明，无论输液管每24小时还是48小时更换一次，静脉炎发生率均无显著差异。此外，48小时和72小时更换穿刺部位的组之间静脉炎发生率也无显著差异。临床上，24小时更换输液管组的患者静脉炎发生率较低。对环境、静脉用药（肝素、氯化钾、抗生素和皮质类固醇）、诊断和年龄等其他因素之间关系的分析显示，无统计学显著关系。得出的结论是，更频繁地更换输液管对患者无害，事实上可能有益。
