Pregnancy rate after homologous insemination of pathological ejaculate both with and without the addition of kallikrein.

As part of a gynecological-andrological cooperation programme for the treatment of infertile marriages made by the 1st Department of Obstetrics and Gynecology and the Department of Urology, University of Vienna Medical School, the pregnancy rates achieved through 1,269 homologous inseminations of pathological ejaculates (according to Elliason's classification) both with and without addition of kallikrein was analysed retrospectively. In the case of 131 married couples, only 5 pregnancies occurred without the addition of kallikrein, and where kallikrein was used, there were also 5 pregnancies in 75 couples (6.66%). No conception occurred when cryoejaculate was used in addition. There were altogether 11 cases of spontaneous pregnancies. Conception could only be induced if an ejaculate of relatively high quality with a spermatozoa count of more than 12 million/ml and a 2-hour motility of more than 28% was used for insemination. The problems associated with homologous insemination with pathological ejaculate are being discussed.