Dujardin P, Cassuto J P, Audoly P, Kermarec J
Ann Med Interne (Paris). 1978 Mar;129(3):165-73.
The authors describe four new cases of allergic granulomatous angiitis presenting symptoms of bronchopneumonia with asthma, weight loss, and persistent fever. There was associated eosinophilia in each case, and the outcome was rapidly fatal. Autopsy confirmed the presence of characteristic lesions; necrotizing angitis, vein involvement, and extra-vascular granulomatous infiltration, mainly in the lungs and heart. The characteristic clinical, biological, and histological changes seen in Churg and Strauss's syndrome should enable differentiation from other granulomatous angititis affections, especially PAN. A different diagnostic approach is needed, however, as surgical biopsy of the lungs, and/or needle biopsy of the liver is necessary.
作者描述了4例变应性肉芽肿性血管炎的新病例，这些病例表现为支气管肺炎伴哮喘、体重减轻和持续发热的症状。每例均伴有嗜酸性粒细胞增多，且预后迅速恶化死亡。尸检证实存在特征性病变；坏死性血管炎、静脉受累以及血管外肉芽肿性浸润，主要累及肺和心脏。在Churg和Strauss综合征中所见的特征性临床、生物学和组织学改变应有助于与其他肉芽肿性血管炎疾病，尤其是结节性多动脉炎相鉴别。然而，由于需要进行肺手术活检和/或肝穿刺活检，因此需要采用不同的诊断方法。
