正常和肝硬化大鼠肝脏中的锁链素和异锁链素含量以及弹性蛋白酶活性
Desmosine and isodesmosine contents and elastase activity in normal and cirrhotic rat liver.
作者信息
Velebný V, Kasafírek E, Kanta J
出版信息
Biochem J. 1983 Sep 15;214(3):1023-5. doi: 10.1042/bj2141023.
Abstract
The contents of desmosine and isodesmosine, the cross-linking amino acids of elastin, were increased 4-fold in rat liver with carbon tetrachloride-induced cirrhosis, which suggests that insoluble elastin accumulates in cirrhosis. Elastase activity in the cirrhotic liver, as determined with 3-carboxypropionyl-L-alanyl-L-alanyl-L-alanine p-nitroanilide, was 17% less than in the normal liver; no change was found when Congo Red-elastin was used as a substrate.
摘要
弹性蛋白的交联氨基酸——锁链素和异锁链素的含量，在四氯化碳诱导的大鼠肝硬化肝脏中增加了4倍，这表明在肝硬化中不溶性弹性蛋白会蓄积。用3-羧基丙酰-L-丙氨酰-L-丙氨酰-L-丙氨酸对硝基苯胺测定的肝硬化肝脏中的弹性蛋白酶活性，比正常肝脏低17%；当以刚果红弹性蛋白作为底物时未发现变化。
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Elastosis in fibrotic and cirrhotic processes of the liver.肝脏纤维化和肝硬化过程中的弹性组织变性
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The structure and chemical characterization of elastic fibers as revealed by elastase and by electron microscopy.弹性蛋白酶和电子显微镜揭示的弹性纤维的结构与化学特性
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Antibodies to desmosine.抗异锁链素抗体。
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