Alonso K B
Ann Clin Lab Sci. 1978 May-Jun;8(3):228-33.
Acute consumptive coagulopathy may be initiated by diverse events. It is frequently necessary to establish the diagnosis with urgency. Rational therapy can only be approached with knowledge of the relative impact the primary consumption exerts upon hemostasis as well as the effects of secondary fibrinolysis. A constellation of interlocking tests within the capability of the small laboratory is presented. This includes the prothrombin time, the activated partial thromboplastin time, the serial thrombin time, the heat precipitation fibrinogen level, the platelet count, red cell morphology, the levels of fibrin (fibrinogen) degradation products and selected factor assays. This series can be completed within 45 minutes. Interpretation, with particular emphasis upon the stage in the natural history of the process when evaluation is instituted, and underlying diseases which modify typical patterns are discussed. The discriminant function of the serial thrombin time is stressed.
急性消耗性凝血病可能由多种事件引发。通常需要紧急进行诊断。只有在了解原发性消耗对止血的相对影响以及继发性纤维蛋白溶解的作用后，才能进行合理的治疗。本文介绍了小型实验室能够开展的一系列相互关联的检测。这包括凝血酶原时间、活化部分凝血活酶时间、连续凝血酶时间、热沉淀纤维蛋白原水平、血小板计数、红细胞形态、纤维蛋白（纤维蛋白原）降解产物水平以及特定因子检测。该系列检测可在45分钟内完成。文中讨论了检测结果的解读，特别强调了进行评估时该过程自然史中的阶段，以及改变典型模式的基础疾病。重点强调了连续凝血酶时间的鉴别功能。
