Meyer J S, Sakai F, Naritomi H, Grant P
Arch Neurol. 1978 Jun;35(6):350-9. doi: 10.1001/archneur.1978.00500300024004.
Cerebrovascular functional reserve was tested by noninvasive measurement of regional cerebral blood flow (nrCBF) at rest in quiet darkness and when repeated during standard multiple psychophysiologic activation. The test was applied to normal volunteers and patients with different neurologic disorders. The test included counting, conversation, music, and observing movements, while rCBF was measured over both cerebral hemispheres, brain stem, and cerebellum. In normal persons at rest, mean gray matter flow (Fg) values were the same for each hemisphere. Highest Fg values were observed in brain stem and both frontal regions. During activation in normal persons, there was a significant increase in Fg values over both hemispheres and in brain stem. During activation, three types of abnormal rCBF responses were seen: Demented patients showed no change, patients with vascular occlusion showed little or no increase over the ischemic hemisphere, and some patients with epilepsy showed excessive increases.
通过在安静黑暗环境中静息时以及在标准的多种心理生理激活过程中重复测量局部脑血流量（nrCBF），对脑血管功能储备进行了无创检测。该检测应用于正常志愿者和患有不同神经系统疾病的患者。检测包括计数、对话、听音乐和观察动作，同时在双侧大脑半球、脑干和小脑测量rCBF。在静息状态下的正常人中，每个半球的平均灰质血流量（Fg）值相同。在脑干和双侧额叶区域观察到最高的Fg值。在正常人激活过程中，双侧半球和脑干的Fg值显著增加。在激活过程中，观察到三种类型的异常rCBF反应：痴呆患者无变化，血管闭塞患者在缺血半球几乎没有增加或没有增加，一些癫痫患者则过度增加。
