Cunha-Vaz J G, Fonseca J R, de Abreu J R, Lima J J
Arch Ophthalmol. 1978 May;96(5):809-11. doi: 10.1001/archopht.1978.03910050415001.
Diabetic patients grouped according to the evolutive stages of their retinal involvement were examined by a direct method for estimation of segmental retinal blood flow by slit-lamp fluorophotometry. Initial stages of retinal involvement in diabetes, in which the only alteration is a breakdown of the blood-retinal barrier, show values of segmental blood flow that are within normal limits. Patients with a minimal background retinopathy show a slight increase in retinal blood flow, whereas an highly significant increase of segmental blood flow is observed in the more advanced stages of background retinopathy with maculopathy. In general, a good correlation is apparent between the progressions of diabetic background retinopathy and increase in retinal blood flow. On the other hand, patients with proliferative retinopathy show lower values of retinal blood flow, which are attributable to a marked decrease in arterial diameter.
根据视网膜病变进展阶段分组的糖尿病患者，通过裂隙灯荧光光度法直接测量节段性视网膜血流进行检查。糖尿病视网膜病变的初始阶段，唯一的改变是血视网膜屏障的破坏，此时节段性血流值在正常范围内。轻度背景性视网膜病变患者的视网膜血流略有增加，而在伴有黄斑病变的背景性视网膜病变更晚期阶段，节段性血流显著增加。一般来说，糖尿病性背景性视网膜病变的进展与视网膜血流增加之间存在明显的相关性。另一方面，增殖性视网膜病变患者的视网膜血流值较低，这归因于动脉直径的显著减小。
