Schirren C, Heckhoff-Hueth B
Andrologia. 1983;15 Spec No:523-5.
73 males with different fertility disturbances (53 X oligozoospermia, 4 X asthenozoospermia and 16 X teratozoospermia) were treated by a combination of mesterolone (50 mg daily) and kallikrein (6 X 100 KU daily; every two hours one tablet); duration of treatment: three months. Before starting the treatment two semen analyses were performed; furthermore semen control at the end of the treatment as well as three and six months after ending the therapy. The sperm density don't demonstrate any changes. The normal morphology of the spermatozoa increased about 10%. In selected cases with a very bad sperm morphology a testicular biopsy were performed; in these cases the percentage of normal spermatozoa increased for about 21%. The motility rate showed no significant changes. It can be demonstrated that this combination don't better effects than other treatment. The best way is a treatment at a well selected material with a special drug for a special case.
73名患有不同生育障碍的男性（53例为少精子症、4例为弱精子症和16例为畸形精子症）接受了甲睾酮（每日50毫克）和激肽释放酶（每日6×100KU；每两小时一片）联合治疗；治疗持续时间：三个月。在开始治疗前进行了两次精液分析；此外，在治疗结束时以及治疗结束后三个月和六个月进行精液检查。精子密度未显示任何变化。精子的正常形态增加了约10%。在精子形态非常差的选定病例中进行了睾丸活检；在这些病例中，正常精子的百分比增加了约21%。活力率没有显著变化。可以证明，这种联合治疗并不比其他治疗有更好的效果。最好的方法是针对特定病例，选用特定药物对精心挑选的患者进行治疗。
