Welker B G, Jecht E W, Hornstein O P
Andrologia. 1982 Sep-Oct;14(5):416-24.
224 infertile men were treated with mesterolone (M.;30, or 60 mg/die) for a minimum of three months. When comparing semen analyses done before and after treatment with M., a small but distinct reduction of hyperspermia as well as an augmentation of hypospermia were evident, an increase of sperm density in oligozoospermia grade I (20-40 kx 10(6) sperm/ml) was revealed, and an improvement of sperm motility in asthenozoospermia was seen. These was no change in sperm morphology. According to our data, careful selection of patients for treatment with M. Based on aetio-pathogenic considerations appears to be the "salient point" in the administration M. As a general rule, treatment with M. should be confined to patients with mild idiopathic oligo (astheno) zoospermia where no specific therapy - such as, e.g., high ligation for varicocele - is available.
224名不育男性接受了甲睾酮（M.；30或60毫克/日）治疗，疗程至少三个月。在比较用M.治疗前后的精液分析结果时，明显发现精液过多有轻微但显著的减少，精液过少则有所增加，I级少精子症（20 - 40×10⁶精子/毫升）患者的精子密度增加，弱精子症患者的精子活力有所改善。精子形态没有变化。根据我们的数据，基于病因学考虑仔细挑选接受M.治疗的患者似乎是使用M.治疗的“关键点”。一般来说，M.治疗应仅限于轻度特发性少（弱）精子症患者，这些患者没有可用的特异性治疗方法，如精索静脉曲张高位结扎术。
