硫酸酯键类型和糖胺聚糖硫酸化程度对其与溶酶体酶相互作用的影响。
The influence of the type of sulphate bond and degree of sulphation of glycosaminoglycans on their interaction with lysosomal enzymes.
作者信息
Avila J L
出版信息
Biochem J. 1978 May 1;171(2):489-91. doi: 10.1042/bj1710489.
Abstract
Significant differences occur between the interaction of several sulphated glycosaminoglycans with a particular lysosomal protein, leading to inhibition in the case of lysosomal enzymes. The order of strength of inhibition at pH4 was: heparin greater than chondroitin 4-sulphate = chondroitin 6-sulphate greater than dermatan sulphate.
摘要
几种硫酸化糖胺聚糖与一种特定溶酶体蛋白的相互作用存在显著差异，这导致在溶酶体酶的情况下产生抑制作用。在pH4时抑制强度的顺序为：肝素大于硫酸软骨素4-硫酸盐 = 硫酸软骨素6-硫酸盐大于硫酸皮肤素。
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本文引用的文献
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The sulfation of chondroitin sulfate in embryonic chick cartilage epiphyses.胚胎期鸡软骨骨骺中硫酸软骨素的硫酸化作用。
J Biol Chem. 1969 Jan 25;244(2):348-52.
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A method for the determination of the molecular weight and molecular-weight distribution of chondroitin sulphate.一种测定硫酸软骨素分子量及分子量分布的方法。
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[The sciatic nerve of the newt Taricha torosa. Its ultrastructural organization and location of its acid phosphatase enzyme activity].
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Interactions between mucopolysaccharides and cationic polypeptides in aqueous solution: Chondroitin 4-sulfate and dermatan sulfate.水溶液中粘多糖与阳离子多肽之间的相互作用：硫酸软骨素4和硫酸皮肤素。
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10
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Biochem J. 1975 Oct;152(1):57-64. doi: 10.1042/bj1520057.
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