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硫酸酯键类型和糖胺聚糖硫酸化程度对其与溶酶体酶相互作用的影响。

The influence of the type of sulphate bond and degree of sulphation of glycosaminoglycans on their interaction with lysosomal enzymes.

作者信息

Avila J L

出版信息

Biochem J. 1978 May 1;171(2):489-91. doi: 10.1042/bj1710489.

DOI:10.1042/bj1710489
PMID:656058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1183980/
Abstract

Significant differences occur between the interaction of several sulphated glycosaminoglycans with a particular lysosomal protein, leading to inhibition in the case of lysosomal enzymes. The order of strength of inhibition at pH4 was: heparin greater than chondroitin 4-sulphate = chondroitin 6-sulphate greater than dermatan sulphate.

摘要

几种硫酸化糖胺聚糖与一种特定溶酶体蛋白的相互作用存在显著差异，这导致在溶酶体酶的情况下产生抑制作用。在pH4时抑制强度的顺序为：肝素大于硫酸软骨素4-硫酸盐 = 硫酸软骨素6-硫酸盐大于硫酸皮肤素。

相似文献

1
The influence of the type of sulphate bond and degree of sulphation of glycosaminoglycans on their interaction with lysosomal enzymes.硫酸酯键类型和糖胺聚糖硫酸化程度对其与溶酶体酶相互作用的影响。
Biochem J. 1978 May 1;171(2):489-91. doi: 10.1042/bj1710489.
2
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引用本文的文献

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Enhancement of cholesterol and cholesteryl ester accumulation in re-endothelialized aorta.再内皮化主动脉中胆固醇和胆固醇酯积累的增强。
Am J Pathol. 1980 Apr;99(1):81-104.
3
Inhibitory effect of heparin on leucocyte chemotactic factors.肝素对白细胞趋化因子的抑制作用。
Clin Exp Immunol. 1980 Feb;39(2):526-31.
4
Ultrastructural cytochemistry of glycoconjugates in basophils from humans and animals.人和动物嗜碱性粒细胞中糖缀合物的超微结构细胞化学
Histochemistry. 1985;83(4):307-13. doi: 10.1007/BF00684376.
5
Mucosubstances of rabbit granulocytes studied by means of electron-microscopic radioautography and X-ray microanalysis.通过电子显微镜放射自显影术和X射线微量分析对兔粒细胞的粘膜物质进行研究。
Histochemistry. 1979 Jun 18;61(2):139-50. doi: 10.1007/BF00496526.

本文引用的文献

1
The sulfation of chondroitin sulfate in embryonic chick cartilage epiphyses.胚胎期鸡软骨骨骺中硫酸软骨素的硫酸化作用。
J Biol Chem. 1969 Jan 25;244(2):348-52.
2
A method for the determination of the molecular weight and molecular-weight distribution of chondroitin sulphate.一种测定硫酸软骨素分子量及分子量分布的方法。
J Chromatogr. 1971 Jul 8;59(1):87-97. doi: 10.1016/s0021-9673(01)80009-1.
3
[The sciatic nerve of the newt Taricha torosa. Its ultrastructural organization and location of its acid phosphatase enzyme activity].
Acta Cient Venez. 1973;24(1):5-18.
4
Interactions between mucopolysaccharides and cationic polypeptides in aqueous solution: Chondroitin 4-sulfate and dermatan sulfate.水溶液中粘多糖与阳离子多肽之间的相互作用：硫酸软骨素4和硫酸皮肤素。
Biopolymers. 1973;12(9):1959-74. doi: 10.1002/bip.1973.360120904.
5
Characterization of glycosaminoglycans in human leukocytes: enzymatic subunit assay of isomeric chondroitin sulfates.
Biochem Med. 1974 Nov;11(3):217-26. doi: 10.1016/0006-2944(74)90118-5.
6
Interactions between mucopolysaccharides and cationic polypeptides in aqueous solution: hyaluronic acid, heparitin sulfate, and keratan sulfate.水溶液中黏多糖与阳离子多肽之间的相互作用：透明质酸、硫酸乙酰肝素和硫酸角质素。
Biopolymers. 1974 Jan;13(1):139-56. doi: 10.1002/bip.1974.360130109.
7
Mucopolysaccharidosis: secondarily induced abnormal distribution of lysosomal isoenzymes.黏多糖贮积症：溶酶体同工酶的继发性异常分布。
Science. 1973 Jul 27;181(4097):352-4. doi: 10.1126/science.181.4097.352.
8
The abnormalities of lysosomal enzymes in mucopolysacc- haridoses.黏多糖贮积症中溶酶体酶的异常。
Eur J Biochem. 1968 Dec;7(1):34-44. doi: 10.1111/j.1432-1033.1968.tb19570.x.
9
Physicochemical characteristics of the glycosaminoglycan-lysosomal enzyme interaction in vitro. A model of control of leucocytic lysosomal activity.体外糖胺聚糖 - 溶酶体酶相互作用的物理化学特性。白细胞溶酶体活性控制模型。
Biochem J. 1976 Nov 15;160(2):129-36. doi: 10.1042/bj1600129.
10
Inhibition of leucocytic lysosomal enzymes by glycosaminoglycans in vitro.体外糖胺聚糖对白细胞溶酶体酶的抑制作用。
Biochem J. 1975 Oct;152(1):57-64. doi: 10.1042/bj1520057.