恶性疾病患者外周血中K细胞活性增强。
Enhanced K-cell activity in the peripheral blood of patients with malignant disease.
作者信息
Bakács T, Czanik P, Kimber I, Ringwald G, Moore M, Abrahám E
出版信息
Cancer Immunol Immunother. 1984;16(3):170-4. doi: 10.1007/BF00205424.
Abstract
We have analysed the influence of human malignant, inflammatory and infectious disease on the capacity of peripheral lymphocytes to mediate antibody-dependent haemolysis. The application of an enzyme-like kinetic model for measurement of maximal cytotoxic function has permitted reproducible and sensitive determinations of the K-cell function. The results show that malignant disease is associated with enhancement of ADCC capacity.
摘要
我们分析了人类恶性疾病、炎症性疾病和感染性疾病对外周淋巴细胞介导抗体依赖性溶血能力的影响。应用一种类似酶的动力学模型来测量最大细胞毒性功能，已能够对K细胞功能进行可重复且灵敏的测定。结果表明，恶性疾病与抗体依赖性细胞介导的细胞毒性（ADCC）能力增强有关。
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