新西兰遗传性高血压大鼠垂体前叶中腺性激肽释放酶样活性降低。
Reduced glandular kallikrein-like activity in the anterior pituitary of the New Zealand genetically hypertensive rat.
作者信息
Powers C A, Baer P G, Nasjletti A
出版信息
Biochem Biophys Res Commun. 1984 Mar 15;119(2):689-93. doi: 10.1016/s0006-291x(84)80305-8.
Anterior pituitaries of New Zealand genetically hypertensive and normotensive rats were compared for their content of glandular kallikrein-like activity. Anterior pituitary homogenates were assayed for their ability to cleave a chromogenic peptide substrate for glandular kallikrein (H-D-val-leu-arg-p-nitroanilide) at pH 8.0. Anterior pituitaries of both male and female New Zealand genetically hypertensive rats contained significantly less glandular kallikrein-like activity than their normotensive counterparts (-55% for females and -31% for males).
比较了新西兰遗传性高血压大鼠和正常血压大鼠垂体前叶中腺激肽释放酶样活性的含量。检测垂体前叶匀浆在pH 8.0条件下切割腺激肽释放酶显色肽底物（H-D-缬氨酸-亮氨酸-精氨酸-对硝基苯胺）的能力。新西兰遗传性高血压大鼠的雄性和雌性垂体前叶中腺激肽释放酶样活性均明显低于正常血压大鼠（雌性降低55%，雄性降低31%）。
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