Zaccaria A, Barbieri E, Mantovani W, Tura S
Boll Ist Sieroter Milan. 1978 Mar 31;57(1):76-83.
The karyotype of peripheral blood lymphocytes has been studied in a group of patients with Hodgkin's disease. Before any therapy, the karyotype was either normal or aneuploid. A few months after radiotherapy (total nodal irradiation) a conspicuous amount of structural chromosome aberrations was found. Three to six years after completion of radiotherapy, the lymphocyte karyotype was almost normal, even if stable ionizing radiation-induced aberrations were still detectable. This is consistent with the normal behaviour of these patients and with the long-lasting effect of radiations on nuclear D.N.A. Owing to the close relationship between ionizing raditions and chromosome aberrations on one hand, and abnormal karyotypes and tumors on the other, it cannot be overlooked that these aberrations may play an important role, together with other carcinogenic factors, in the development of second malignancies in these patients.
对一组霍奇金病患者的外周血淋巴细胞核型进行了研究。在任何治疗之前，核型要么正常，要么为非整倍体。放射治疗（全淋巴结照射）几个月后，发现了大量明显的染色体结构畸变。放射治疗结束三至六年之后，淋巴细胞核型几乎正常，即便仍可检测到稳定的电离辐射诱导的畸变。这与这些患者的正常表现以及辐射对核DNA的长期影响是一致的。鉴于电离辐射与染色体畸变之间一方面存在密切关系，另一方面异常核型与肿瘤之间也存在密切关系，不能忽视的是，这些畸变可能与其他致癌因素一起，在这些患者的第二原发恶性肿瘤发生过程中发挥重要作用。
