Agoston S, Vermeer G A, Kersten U W, Scaf A H
Br J Anaesth. 1978 Apr;50(4):345-51. doi: 10.1093/bja/50.4.345.
The fate of gallamine triethiodide has been investigated in patients undergoing cholecystectomy with choledochostomy (group I), pelvic operations (group II) and orthopaedic operations (group III). Following a single i.v. injection of gallamine 2.5 mg kg(-1) the disappearance of the drug from the serum occurred in three phases with half-lives of less than 5, 30, 138 min, less than 5, 39, 141 and less than 5, 48, 144 min in the respective groups. Twenty-four hours after injection the renal excretion of the unchanged drug was 53% (15-100%) of the administered dose in group I, 67% (40-90%) in group II and 95% (89-100%) in group III. The biliary excretion of gallamine appeared to be negligible in man. The relationship between renal excretion and duration of action of gallamine, and the influence of some intraoperative factors on drug disposition, are discussed.
已对接受胆囊切除术并胆总管造口术的患者（第一组）、盆腔手术患者（第二组）和骨科手术患者（第三组）中三碘季铵酚的转归进行了研究。静脉单次注射2.5mg/kg三碘季铵酚后，药物从血清中的消失呈三个阶段，各相应组的半衰期分别小于5、30、138分钟，小于5、39、141分钟以及小于5、48、144分钟。注射后24小时，第一组中未变化药物的肾排泄量为给药剂量的53%（15 - 100%），第二组为67%（40 - 90%），第三组为95%（89 - 100%）。三碘季铵酚的胆汁排泄在人体中似乎可忽略不计。文中讨论了三碘季铵酚的肾排泄与作用持续时间之间的关系，以及一些术中因素对药物处置的影响。
