4-氨基吡啶对伊顿-兰伯特综合征的影响。
Effects of 4-aminopyridine in Eaton Lambert Syndrome.
作者信息
Agoston S, van Weerden T, Westra P, Broekert A
出版信息
Br J Anaesth. 1978 Apr;50(4):383-5. doi: 10.1093/bja/50.4.383.
PMID:656256
Abstract
The effects of 4-aminopyridine (a non-anticholinesterase antagonist of curare-like agents) on the evoked muscle action potentials (EMAP) in a patient with Eaton Lambert Syndrome are reported. On two separate occasions the i.v. administration of 0.31 mg kg(-1) and 0.62 mg kg(-1) was followed by a 300% increase of EMAP for about 2 h without serious side-effects.
摘要
报道了4-氨基吡啶（一种箭毒样药物的非抗胆碱酯酶拮抗剂）对一名伊顿-兰伯特综合征患者诱发肌肉动作电位（EMAP）的影响。在两个不同的时间点，静脉注射0.31 mg/kg和0.62 mg/kg后，EMAP增加了约300%，持续约2小时，且无严重副作用。
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