美托洛尔和氧烯洛尔的血浆与唾液水平比较。
Comparison of plasma and saliva levels of metoprolol and oxprenolol.
作者信息
Dawes C P, Kendall M J, John V A
出版信息
Br J Clin Pharmacol. 1978 Mar;5(3):217-21. doi: 10.1111/j.1365-2125.1978.tb01627.x.
Abstract
1 Plasma and saliva levels of metoprolol and oxprenolol have been compared in two groups of healthy volunteers. 2 Mean salivary oxprenolol levels were lower than, but closely related to the corresponding plasma levels (r=0.93), the mean ratio of saliva:plasma concentration being 0.42. 3 Mean salivary metoprolol concentrations were considerably greater thatn the corresponding plasma levels and the relationship between the concentrations in the two fluids was less clear. 4 The evidence presented suggests that oxprenolol diffuses passively whilst metoprolol is actively secreted into saliva. The mechanism involved in the active process is not known.
摘要
- 已对两组健康志愿者的血浆和唾液中美托洛尔和氧烯洛尔的水平进行了比较。2. 唾液中氧烯洛尔的平均水平低于相应的血浆水平，但两者密切相关（r = 0.93），唾液与血浆浓度的平均比值为0.42。3. 唾液中美托洛尔的平均浓度远高于相应的血浆水平，两种液体中浓度之间的关系不太明确。4. 所提供的证据表明，氧烯洛尔被动扩散，而美托洛尔则被主动分泌到唾液中。主动过程所涉及的机制尚不清楚。
相似文献
1
Comparison of plasma and saliva levels of metoprolol and oxprenolol.美托洛尔和氧烯洛尔的血浆与唾液水平比较。
Br J Clin Pharmacol. 1978 Mar;5(3):217-21. doi: 10.1111/j.1365-2125.1978.tb01627.x.
2
A comparison of the pharmacokinetics of atenolol, metoprolol, oxprenolol and propranolol in elderly hypertensive and young healthy subjects.阿替洛尔、美托洛尔、氧烯洛尔和普萘洛尔在老年高血压患者和年轻健康受试者体内的药代动力学比较。
Br J Clin Pharmacol. 1985 Oct;20(4):327-31. doi: 10.1111/j.1365-2125.1985.tb05072.x.
3
Evaluation of oxprenolol and metoprolol Oros systems in the dog: comparison of in vivo and in vitro drug release, and of drug absorption from duodenal and colonic infusion sites.犬体内氧烯洛尔和美托洛尔渗透泵系统的评价：体内外药物释放及十二指肠和结肠输注部位药物吸收的比较
Br J Clin Pharmacol. 1985;19 Suppl 2(Suppl 2):91S-95S. doi: 10.1111/j.1365-2125.1985.tb02748.x.
4
Gastrointestinal transit of Oros drug delivery systems in healthy volunteers: a short report.健康志愿者中口服药物递送系统的胃肠道转运：简短报告
Br J Clin Pharmacol. 1985;19 Suppl 2(Suppl 2):203S-206S. doi: 10.1111/j.1365-2125.1985.tb02763.x.
5
A comparison of the effects of the slow release formulations of metoprolol and oxprenolol in hypertension.美托洛尔和氧烯洛尔缓释制剂治疗高血压的效果比较。
Ann Clin Res. 1982 Feb;14(1):27-31.
6
Gas chromatographic determination of metoprolol in human plasma.气相色谱法测定人血浆中的美托洛尔。
J Chromatogr. 1983 Jan 14;272(1):103-10. doi: 10.1016/s0378-4347(00)86107-1.
7
Effect of inflammatory disease on plasma concentrations of three beta-adrenoceptor blocking agents.
Int J Clin Pharmacol Ther Toxicol. 1981 Apr;19(4):158-62.
8
The effect of age on the pharmacokinetics of metoprolol and its metabolites.年龄对美托洛尔及其代谢产物药代动力学的影响。
Br J Clin Pharmacol. 1981 Mar;11(3):287-94. doi: 10.1111/j.1365-2125.1981.tb00536.x.
9
Determination of metoprolol enantiomers in human plasma and saliva samples utilizing microextraction by packed sorbent and liquid chromatography-tandem mass spectrometry.采用填充吸附剂微萃取和液相色谱-串联质谱法测定人血浆和唾液样本中的美托洛尔对映体。
Biomed Chromatogr. 2016 Aug;30(8):1309-17. doi: 10.1002/bmc.3685. Epub 2016 Feb 29.
10
The effect of impaired renal function on the plasma concentration and urinary excretion of metoprolol metabolites.肾功能受损对美托洛尔代谢物血浆浓度及尿排泄的影响。
Clin Pharmacokinet. 1980 Mar-Apr;5(2):181-91. doi: 10.2165/00003088-198005020-00005.
引用本文的文献
1
The basel cocktail for simultaneous phenotyping of human cytochrome P450 isoforms in plasma, saliva and dried blood spots.用于同时对血浆、唾液和干血斑中的人细胞色素P450同工型进行表型分析的巴塞尔鸡尾酒法。
Clin Pharmacokinet. 2014 Mar;53(3):271-282. doi: 10.1007/s40262-013-0115-0.
2
Time-dependent variability of chloroquine secretion into human saliva.氯喹分泌至人唾液中的时间依赖性变异性。
Pharm World Sci. 1996 Dec;18(6):211-6. doi: 10.1007/BF00735962.
3
Quantitative relationships between structure and pharmacokinetics of beta-adrenoceptor blocking agents in man.人体内β-肾上腺素受体阻滞剂的结构与药代动力学之间的定量关系。
J Pharmacokinet Biopharm. 1984 Jun;12(3):263-87. doi: 10.1007/BF01061721.
4
Salivary concentrations of pirmenol as a possible cause of unpleasant taste.吡美诺的唾液浓度可能是导致味觉不适的一个原因。
Br J Clin Pharmacol. 1986 Nov;22(5):613-5. doi: 10.1111/j.1365-2125.1986.tb02944.x.
5
Acebutolol saliva excretion.醋丁洛尔唾液排泄
Br J Clin Pharmacol. 1979 Oct;8(4):373-5. doi: 10.1111/j.1365-2125.1979.tb04724.x.
本文引用的文献
1
Nitrogenous substances in saliva. 2. Urea and rhodan.唾液中的含氮物质。2. 尿素与硫氰酸。
Jpn J Physiol. 1952 Jul;2(4):255-9. doi: 10.2170/jjphysiol.2.255.
2
The permeability of the human parotid gland to a series of sulfonamide compounds, para-aminohippurate and inulin.人类腮腺对一系列磺胺类化合物、对氨基马尿酸盐和菊粉的通透性。
Scand J Clin Lab Invest. 1955;7(1):86-91. doi: 10.3109/00365515509134102.
3
The excretion of drugs in saliva. Antibiotics.
J Oral Ther Pharmacol. 1965 Nov;2(3):180-7.
4
The use of salivary (parotid) fluid in biochemical monitoring.唾液（腮腺）液在生化监测中的应用。
Am Ind Hyg Assoc J. 1969 Jan-Feb;30(1):77-82. doi: 10.1080/00028896909343083.
5
Application of salivary salicylate data to biopharmaceutical studies of salicylates.唾液水杨酸数据在水杨酸盐生物制药研究中的应用。
J Pharm Sci. 1972 Aug;61(8):1219-22. doi: 10.1002/jps.2600610810.
6
Relationship between theophylline concentration in plasma and saliva of man.
Clin Pharmacol Ther. 1974 May;15(5):454-60. doi: 10.1002/cpt1974155454.
7
Pharmacokinetics of tolbutamide: prediction by concentration in saliva.甲苯磺丁脲的药代动力学：通过唾液浓度进行预测。
Clin Pharmacol Ther. 1974 Dec;16(6):1052-8. doi: 10.1002/cpt19741661052.
8
Binding of two adrenergic beta-receptor antagonists, alprenolol and H 93-26, to human serum proteins.两种肾上腺素能β受体拮抗剂阿普洛尔和H 93 - 26与人血清蛋白的结合。
Acta Pharm Suec. 1974 Sep;11(4):333-46.
9
Salivary excretion of paracetamol in man.
J Pharm Pharmacol. 1973 May;25(5):420-1. doi: 10.1111/j.2042-7158.1973.tb10042.x.
10
Assessment of antipyrine kinetics by measurement in saliva.通过唾液测量评估安替比林动力学。
Br J Clin Pharmacol. 1976 Apr;3(2):321-5. doi: 10.1111/j.1365-2125.1976.tb00610.x.
Zotero 插件