美托洛尔和氧烯洛尔的血浆与唾液水平比较。
Comparison of plasma and saliva levels of metoprolol and oxprenolol.
作者信息
Dawes C P, Kendall M J, John V A
出版信息
Br J Clin Pharmacol. 1978 Mar;5(3):217-21. doi: 10.1111/j.1365-2125.1978.tb01627.x.
Abstract
1 Plasma and saliva levels of metoprolol and oxprenolol have been compared in two groups of healthy volunteers. 2 Mean salivary oxprenolol levels were lower than, but closely related to the corresponding plasma levels (r=0.93), the mean ratio of saliva:plasma concentration being 0.42. 3 Mean salivary metoprolol concentrations were considerably greater thatn the corresponding plasma levels and the relationship between the concentrations in the two fluids was less clear. 4 The evidence presented suggests that oxprenolol diffuses passively whilst metoprolol is actively secreted into saliva. The mechanism involved in the active process is not known.
摘要
- 已对两组健康志愿者的血浆和唾液中美托洛尔和氧烯洛尔的水平进行了比较。2. 唾液中氧烯洛尔的平均水平低于相应的血浆水平，但两者密切相关（r = 0.93），唾液与血浆浓度的平均比值为0.42。3. 唾液中美托洛尔的平均浓度远高于相应的血浆水平，两种液体中浓度之间的关系不太明确。4. 所提供的证据表明，氧烯洛尔被动扩散，而美托洛尔则被主动分泌到唾液中。主动过程所涉及的机制尚不清楚。
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