通过唾液测量评估安替比林动力学。
Assessment of antipyrine kinetics by measurement in saliva.
作者信息
Fraser H S, Mucklow J C, Murray S, Davies D S
出版信息
Br J Clin Pharmacol. 1976 Apr;3(2):321-5. doi: 10.1111/j.1365-2125.1976.tb00610.x.
Abstract
The half-life of antipyrine has been estimated from saliva samples in ten subjects by a gas chromatographic method. Half-life, apparent volume of distribution and total body clearance estimated from saliva and plasma concentrations of antipyrine are not significantly different. The concentration of antipyrine in saliva is independent of flow rate within the range expected in healthy subjects in response to mechanical and sapid stimuli. Antipyrine estimation in saliva could facilitate many areas of phaamacokinetic research limited by the difficulty of obtaining serial plasma samples.
摘要
采用气相色谱法，通过唾液样本对10名受试者的安替比林半衰期进行了估算。根据安替比林的唾液和血浆浓度估算出的半衰期、表观分布容积和全身清除率并无显著差异。在健康受试者因机械和味觉刺激而产生的预期流速范围内，唾液中安替比林的浓度与流速无关。唾液中安替比林的估算有助于解决许多受连续采集血浆样本困难所限的药代动力学研究领域的问题。
相似文献
1
Assessment of antipyrine kinetics by measurement in saliva.通过唾液测量评估安替比林动力学。
Br J Clin Pharmacol. 1976 Apr;3(2):321-5. doi: 10.1111/j.1365-2125.1976.tb00610.x.
2
A comparative study of antipyrine pharmacokinetics in saliva and plasma using a colourimetric method of antipyrine analysis.
Clin Exp Pharmacol Physiol. 1977 Nov-Dec;4(6):593-6. doi: 10.1111/j.1440-1681.1977.tb02691.x.
3
Comparison of the half-life of antipyrine in plasma, whole blood and saliva of man.
Eur J Clin Pharmacol. 1976 Feb 6;9(4):327-32. doi: 10.1007/BF00561668.
4
Antipyrine: radioimmunoassay in plasma and saliva following administration of a high dose and a low dose.
Clin Pharmacol Ther. 1976 Aug;20(2):219-26. doi: 10.1002/cpt1976202219.
5
Application of salivary concentration data to pharmacokinetic studies with antipyrine.
J Pharm Sci. 1977 Jan;66(1):135-7. doi: 10.1002/jps.2600660140.
6
A sensitive gas-chromatographic assay using a nitrogen-phosphorus detector for determination of antipyrine and aminopyrine in biological fluids.一种使用氮磷检测器的灵敏气相色谱分析法，用于测定生物流体中的安替比林和氨基比林。
Pharmacology. 1979;19(5):228-36. doi: 10.1159/000137317.
7
Saliva and plasma clearance of antipyrine as reflectors of liver function.安替比林的唾液和血浆清除率作为肝功能的反映指标。
Eur J Drug Metab Pharmacokinet. 1981;6(4):261-4. doi: 10.1007/BF03189523.
8
Studies on the disposition of antipyrine, aminopyrine, and phenacetin using plasma, saliva, and urine.利用血浆、唾液和尿液对安替比林、氨基比林和非那西丁进行的处置研究。
Clin Pharmacol Ther. 1975 Sep;18(3):259-72. doi: 10.1002/cpt1975183259.
9
Assessment of antipyrine kinetics from saliva or plasma: influence of age.
J Pharm Biomed Anal. 1995 Aug;13(9):1141-5. doi: 10.1016/0731-7085(95)01531-o.
10
Plasma antipyrine half-life can be determined from urine data.血浆安替比林半衰期可根据尿液数据来确定。
Br J Clin Pharmacol. 1987 Jun;23(6):715-9. doi: 10.1111/j.1365-2125.1987.tb03106.x.
引用本文的文献
1
Improved dialytic removal of protein-bound uraemic toxins with use of albumin binding competitors: an in vitro human whole blood study.使用白蛋白结合竞争剂改善对蛋白结合尿毒症毒素的透析清除：一项体外人全血研究。
Sci Rep. 2016 Mar 22;6:23389. doi: 10.1038/srep23389.
2
Time-dependent variability of chloroquine secretion into human saliva.
Pharm World Sci. 1996 Dec;18(6):211-6. doi: 10.1007/BF00735962.
3
Drug metabolism in white vegetarians.白种素食者的药物代谢
Br J Clin Pharmacol. 1980 May;9(5):523-5. doi: 10.1111/j.1365-2125.1980.tb05853.x.
4
Environmental factors affecting paracetamol metabolism in London factory and office workers.影响伦敦工厂和办公室工作人员对乙酰氨基酚代谢的环境因素。
Br J Clin Pharmacol. 1980 Jul;10(1):67-74. doi: 10.1111/j.1365-2125.1980.tb00503.x.
5
The effects of age and smoking upon antipyrine metabolism.年龄和吸烟对安替比林代谢的影响。
Br J Clin Pharmacol. 1980 Jun;9(6):613-4. doi: 10.1111/j.1365-2125.1980.tb01089.x.
6
Antipyrene clearance in Indian villagers.印度村民中安替比林清除率
Br J Clin Pharmacol. 1980 Apr;9(4):387-94. doi: 10.1111/j.1365-2125.1980.tb01066.x.
7
Antipyrine elimination in saliva after low-dose combined or progestogen-only oral contraceptive steroids.低剂量复方或仅含孕激素口服避孕甾体激素后唾液中安替比林的消除情况
Br J Clin Pharmacol. 1982 Feb;13(2):229-32. doi: 10.1111/j.1365-2125.1982.tb01362.x.
8
Family study of antipyrine clearance.安替比林清除率的家族研究。
Br Med J (Clin Res Ed). 1982 Jan 16;284(6310):150-2. doi: 10.1136/bmj.284.6310.150.
9
Antipyrine clearance in psoriasis.银屑病中安替比林清除率
Br Med J (Clin Res Ed). 1981 Jan 3;282(6257):20-1. doi: 10.1136/bmj.282.6257.20.
10
Reduction of antipyrine clearance in psoriasis.银屑病中安替比林清除率的降低。
Br J Clin Pharmacol. 1984 Mar;17(3):331-3. doi: 10.1111/j.1365-2125.1984.tb02349.x.
本文引用的文献
1
The permeability of the human parotid gland to a series of sulfonamide compounds, para-aminohippurate and inulin.人类腮腺对一系列磺胺类化合物、对氨基马尿酸盐和菊粉的通透性。
Scand J Clin Lab Invest. 1955;7(1):86-91. doi: 10.3109/00365515509134102.
2
Application of salivary salicylate data to biopharmaceutical studies of salicylates.唾液水杨酸数据在水杨酸盐生物制药研究中的应用。
J Pharm Sci. 1972 Aug;61(8):1219-22. doi: 10.1002/jps.2600610810.
3
Relationship between theophylline concentration in plasma and saliva of man.
Clin Pharmacol Ther. 1974 May;15(5):454-60. doi: 10.1002/cpt1974155454.
4
Circadian rhythms in the flow rate and proportional contribution of parotid to whole saliva volume in man.
Arch Oral Biol. 1973 Sep;18(9):1145-53. doi: 10.1016/0003-9969(73)90088-5.
5
Pharmacokinetics of tolbutamide: prediction by concentration in saliva.甲苯磺丁脲的药代动力学：通过唾液浓度进行预测。
Clin Pharmacol Ther. 1974 Dec;16(6):1052-8. doi: 10.1002/cpt19741661052.
6
Gas chromatographic assessment of the reproducibility of phenazone plasma half-life in young healthy volunteers.
Eur J Clin Pharmacol. 1974 Aug 23;7(5):381-5. doi: 10.1007/BF00558211.
7
Interindividual differences in rates of drug oxidation in man.人类药物氧化速率的个体差异。
Drug Metab Dispos. 1973 Jan-Feb;1(1):411-7.
Zotero 插件