Teichmann A T, Wieland H, Cremer P, Kuhn W, Seidel D
Geburtshilfe Frauenheilkd. 1984 Mar;44(3):171-6. doi: 10.1055/s-2008-1036873.
The Lipoprotein profile of 24 patients with endometriosis was determined before, during and after the treatment with the two steroid hormones Lynestrenol (10 mg/day) and Danazol (600-800 mg/day). The total cholesterol triglycerides, beta-, prebeta-, and Alphalipo -protein bound to cholesterol were determined. Both hormones cause a marked lowering of the Alpha-Lp-cholesterin. In addition, the beta-LP-cholesterin was elevated and the beta-alpha-LP-ratio was elevated. In the dosage used by us, Lynestrenol showed less effect on the Lipoprotein profile. Danazol caused changed in the beta- and alpha-lipoprotein pattern of highly pathological atherogenic types. The total cholesterol was not influenced. Since women in the fertile age group will suffer a higher risk of arteriosclerosis from an elevation of the beta-LP-cholesterin, the treatment with Danazol calls for a sophisticated monitoring of the lipid metabolism and care in the indication for long term treatment with Danazol or with Lynestrenol.
测定了24例子宫内膜异位症患者在使用两种甾体激素炔诺酮（10毫克/天）和达那唑（600 - 800毫克/天）治疗前、治疗期间和治疗后的脂蛋白谱。测定了总胆固醇、甘油三酯、与胆固醇结合的β - 脂蛋白、前β - 脂蛋白和α - 脂蛋白。两种激素均导致α - 脂蛋白胆固醇显著降低。此外，β - 脂蛋白胆固醇升高，β - α脂蛋白比值升高。在我们使用的剂量下，炔诺酮对脂蛋白谱的影响较小。达那唑导致高度病理性动脉粥样硬化类型的β - 和α - 脂蛋白模式发生变化。总胆固醇不受影响。由于育龄期女性因β - 脂蛋白胆固醇升高会面临更高的动脉硬化风险，因此使用达那唑治疗需要对脂质代谢进行精细监测，并谨慎考虑达那唑或炔诺酮长期治疗的适应症。
